Medically reviewed by Drugs.com. Last updated on Feb 1, 2019.
Applies to the following strengths: 10 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Lambert-Eaton Myasthenic Syndrome
Initial dose: 15 mg to 30 mg orally daily in divided doses (3 to 4 times daily); dose may be increased by 5 mg daily every 3 or 4 days
-Maximum single dose: 20 mg
-Maximum daily dose: 80 mg/day
-If a dose is missed, patients should not take double or extra doses.
Use: For the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults
Renal Dose Adjustments
Mild (CrCl 60 to less than 90 mL/min), moderate (CrCl 30 to less than 60 mL/min), or severe (CrCl 15 to less than 30 mL/min) renal impairment: The recommended starting dose is 15 mg orally daily in 3 divided doses.
End-stage (CrCl less than 15 mL/min) renal disease: Data not available
Liver Dose Adjustments
The recommended starting dosage of FIRDAPSE in patients with any degree of hepatic impairment is 15 mg orally daily in 3 divided doses.
Known N-acetyltransferase 2 (NAT2) Poor Metabolizers:
-Initial dose is 15 mg orally daily in 3 divided doses.
-Hypersensitivity to the active component or any of the ingredients
-History of seizures
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-This drug can be taken with or without food.
-The tablets may be divided in half at the score, if needed.
-Do not take a double dose to make up for a missed dose.
-Store tablets at 20C to 25C with excursions permitted from 15C to 30C (59F to 86F).
-Read the patient information leaflet before taking this drug.
-Seek medical help immediately if you experience hypersensitivity or seizures.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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