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Yohimex (yohimbine) Disease Interactions

There are 5 disease interactions with Yohimex (yohimbine):

Major

Yohimbine (Includes Yohimex) ↔ Cardiovascular Disease

Severe Potential Hazard, High plausibility

Applies to: Hypertension, Heart Disease

Yohimbine can cause hypertension and tachycardia at recommended dosages. Large doses may cause hypotension and cardiac conduction disturbances. Therapy with yohimbine is generally not recommended in patients with hypertension, angina pectoris, or heart disease.

References

  1. Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
  2. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.
  3. Grossman E, Rosenthal T, Peleg E, Holmes C, Goldstein DS "Oral yohimbine increases blood pressure and sympathetic nervous outflow in hypertensive patients." J Cardiovasc Pharmacol 22 (1993): 22-6
  4. Mansoor GA "Herbs and alternative therapies in the hypertension clinic." Am J Hypertens 14(9 Pt 1) (2001): 971-5
View all 4 references
Major

Yohimbine (Includes Yohimex) ↔ Peptic Ulcer Disease

Severe Potential Hazard, High plausibility

Applies to: Peptic Ulcer, History - Peptic Ulcer

Yohimbine may increase gastric acid secretion and gastrointestinal motility secondary to its cholinergic activity. Therapy with yohimbine is generally not recommended in patients with a history of peptic ulcer disease.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.
Major

Yohimbine (Includes Yohimex) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

The use of yohimbine is contraindicated in patients with renal impairment. Yohimbine has mild antidiuretic effects, probably via stimulation of hypothalamic centers and release of posterior pituitary hormone. Agents that reduce or suppress diuresis may aggravate renal diseases.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.
Moderate

Yohimbine (Includes Yohimex) ↔ Depression/Psychoses

Moderate Potential Hazard, Moderate plausibility

Applies to: Psychosis, Anxiety/Stress, Depression, History - Psychiatric Disorder

Yohimbine readily penetrates the blood-brain barrier and may cause anxiety, excitation, and other adverse nervous system effects. Precipitation or exacerbation of psychotic symptoms has been reported. Therapy with yohimbine should be administered cautiously in patients with anxiety, depression, or a history of psychiatric disorders.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.
Moderate

Yohimbine (Includes Yohimex) ↔ Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Data are limited concerning the use of yohimbine in patients with liver disease. Yohimbine is thought to undergo metabolism in the liver. Therapy with yohimbine should be administered cautiously in patients with significantly impaired hepatic function.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.

Yohimex (yohimbine) drug Interactions

There are 30 drug interactions with Yohimex (yohimbine)

Yohimex (yohimbine) alcohol/food Interactions

There is 1 alcohol/food interaction with Yohimex (yohimbine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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