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Mederek Disease Interactions

There are 5 disease interactions with Mederek (yohimbine).

Major

Yohimbine (applies to Mederek) cardiovascular disease

Major Potential Hazard, High plausibility. Applicable conditions: Hypertension, Heart Disease

Yohimbine can cause hypertension and tachycardia at recommended dosages. Large doses may cause hypotension and cardiac conduction disturbances. Therapy with yohimbine is generally not recommended in patients with hypertension, angina pectoris, or heart disease.

References

  1. Limbird LE eds., Gilman AG, Hardman JG "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: McGraw-Hill (1995):
  2. "Product Information. Yocon (yohimbine)." Glenwood Inc PROD (2001):
  3. Grossman E, Rosenthal T, Peleg E, Holmes C, Goldstein DS "Oral yohimbine increases blood pressure and sympathetic nervous outflow in hypertensive patients." J Cardiovasc Pharmacol 22 (1993): 22-6
  4. Mansoor GA "Herbs and alternative therapies in the hypertension clinic." Am J Hypertens 14(9 Pt 1) (2001): 971-5
View all 4 references
Major

Yohimbine (applies to Mederek) peptic ulcer disease

Major Potential Hazard, High plausibility. Applicable conditions: History - Peptic Ulcer

Yohimbine may increase gastric acid secretion and gastrointestinal motility secondary to its cholinergic activity. Therapy with yohimbine is generally not recommended in patients with a history of peptic ulcer disease.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc PROD (2001):
Major

Yohimbine (applies to Mederek) renal dysfunction

Major Potential Hazard, High plausibility.

The use of yohimbine is contraindicated in patients with renal impairment. Yohimbine has mild antidiuretic effects, probably via stimulation of hypothalamic centers and release of posterior pituitary hormone. Agents that reduce or suppress diuresis may aggravate renal diseases.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc PROD (2001):
Moderate

Yohimbine (applies to Mederek) depression/psychoses

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Psychosis, Anxiety/Stress, History - Psychiatric Disorder

Yohimbine readily penetrates the blood-brain barrier and may cause anxiety, excitation, and other adverse nervous system effects. Precipitation or exacerbation of psychotic symptoms has been reported. Therapy with yohimbine should be administered cautiously in patients with anxiety, depression, or a history of psychiatric disorders.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc PROD (2001):
Moderate

Yohimbine (applies to Mederek) liver disease

Moderate Potential Hazard, Moderate plausibility.

Data are limited concerning the use of yohimbine in patients with liver disease. Yohimbine is thought to undergo metabolism in the liver. Therapy with yohimbine should be administered cautiously in patients with significantly impaired hepatic function.

References

  1. "Product Information. Yocon (yohimbine)." Glenwood Inc PROD (2001):

Mederek drug interactions

There are 32 drug interactions with Mederek (yohimbine).

Mederek alcohol/food interactions

There is 1 alcohol/food interaction with Mederek (yohimbine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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