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Voxelotor Disease Interactions

There are 2 disease interactions with voxelotor.

Moderate

Voxelotor (applies to voxelotor) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Dose reduction for voxelotor is recommended for patients with severe hepatic impairment. The daily recommended dose for these patients is 1,000 mg. No dosage adjustment is required for patients with mild or moderate hepatic impairment.

References

  1. "Product Information. Oxbryta (voxelotor)." Global Blood Therapeutics, Inc. (2019):
Moderate

Voxelotor (applies to voxelotor) hypersensitivity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Allergies

Serious hypersensitivity reactions have occurred in patients treated with voxelotor. If hypersensitivity reactions occur, discontinue treatment and administer appropriate medical therapy. Do not reinitiate voxelotor in patients who experience hypersensitivity reactions with previous use.

References

  1. "Product Information. Oxbryta (voxelotor)." Global Blood Therapeutics, Inc. (2019):

Voxelotor drug interactions

There are 353 drug interactions with voxelotor.

Voxelotor alcohol/food interactions

There is 1 alcohol/food interaction with voxelotor.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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