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Ursodiol Disease Interactions

There are 2 disease interactions with ursodiol.


Ursodiol (applies to ursodiol) biliary obstruction

Major Potential Hazard, Moderate plausibility.

The use of ursodiol is contraindicated in patients with compelling reasons for cholecystectomy including unremitting acute cholecystitis, cholangitis, biliary obstruction, gallstone pancreatitis, or biliary gastrointestinal fistula.


  1. (2022) "Product Information. Actigall (ursodiol)." Novartis Pharmaceuticals
  2. (2001) "Product Information. Urso (ursodiol)." Scandipharm Inc

Ursodiol (applies to ursodiol) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Ursodiol therapy has not been associated with liver damage. However, patients given ursodiol should have liver function tests and bilirubin levels measured at the initiation of therapy and every month for three months after start of therapy, and every six months thereafter as appropriate. Close monitoring should be exercised in patients with liver impairment. Treatment discontinuation should be considered if the above parameters increase to a level considered clinically significant.


  1. (2022) "Product Information. Actigall (ursodiol)." Novartis Pharmaceuticals
  2. (2001) "Product Information. Urso (ursodiol)." Scandipharm Inc

Ursodiol drug interactions

There are 4 drug interactions with ursodiol.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.