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Briumvi Disease Interactions

There are 3 disease interactions with Briumvi (ublituximab).

Major

Ublituximab (applies to Briumvi) hepatitis

Major Potential Hazard, Moderate plausibility. Applicable conditions: Infectious Hepatitis

The use of ublituximab is contraindicated in patients with active hepatitis B virus infection.

Moderate

Ublituximab (applies to Briumvi) infections

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral

Serious, including life-threatening and fatal infections, have occurred in patients using ublituximab. Delay treatment in patients with an active infection until the infection is resolved. Vaccination with live-attenuated or
live vaccines is not recommended during treatment with ublituximab and after discontinuation, until B-cell repletion.

Moderate

Ublituximab (applies to Briumvi) renal/hepatic

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease

The effect of moderate to severe renal impairment or moderate to severe hepatic impairment on the pharmacokinetics of ublituximab is unknown.

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Briumvi drug interactions

There are 422 drug interactions with Briumvi (ublituximab).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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