Tretinoin Disease Interactions

Elevated liver enzymes have been reported in 50% to 60% of patients administered tretinoin. These abnormalities are usually reversible, however, patients with hepatic impairment may be at increased risk of hepatotoxicity associated with tretinoin. Clinical monitoring of hepatic function is necessary and consideration should be given to withholding tretinoin therapy if enzyme levels reach 5 times the upper limit of normal values.

A reversible elevation of cholesterol and/or triglycerides has been reported in up to 60% of patients administered tretinoin. Venous thrombosis and myocardial infarction have occurred in patients at low risk for such complications. Therapy with tretinoin should be administered cautiously in patients with or predisposed to hypercholesterolemia and/or hypertriglyceridemia. Clinical monitoring of lipid profile is recommended.