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Tretinoin Disease Interactions

There are 2 disease interactions with tretinoin.


Tretinoin (applies to tretinoin) hepatic dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease

Elevated liver enzymes have been reported in 50% to 60% of patients administered tretinoin. These abnormalities are usually reversible, however, patients with hepatic impairment may be at increased risk of hepatotoxicity associated with tretinoin. Clinical monitoring of hepatic function is necessary and consideration should be given to withholding tretinoin therapy if enzyme levels reach 5 times the upper limit of normal values.


  1. (2001) "Product Information. Vesanoid (tretinoin)." Roche Laboratories

Tretinoin (applies to tretinoin) hyperlipidemia

Moderate Potential Hazard, High plausibility.

A reversible elevation of cholesterol and/or triglycerides has been reported in up to 60% of patients administered tretinoin. Venous thrombosis and myocardial infarction have occurred in patients at low risk for such complications. Therapy with tretinoin should be administered cautiously in patients with or predisposed to hypercholesterolemia and/or hypertriglyceridemia. Clinical monitoring of lipid profile is recommended.


  1. (2001) "Product Information. Vesanoid (tretinoin)." Roche Laboratories

Tretinoin drug interactions

There are 158 drug interactions with tretinoin.

Tretinoin alcohol/food interactions

There is 1 alcohol/food interaction with tretinoin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.