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Telbivudine Disease Interactions

There are 3 disease interactions with telbivudine:

Major

Azt/Telbivudine (Includes Telbivudine) ↔ Myopathy

Severe Potential Hazard, High plausibility

Applies to: Myopathy, Myoneural Disorder

Prolonged use of certain nucleoside reverse transcriptase inhibitors (NRTIs) such as zidovudine and telbivudine may commonly cause myopathy, including rare cases of rhabdomyolysis. The myopathy may be dose-related and is characterized by persistent, unexplained muscle aches and/or weakness in conjunction with increases in creatine phosphokinase (CPK) values. Therapy with these NRTIs should be administered cautiously in patients with preexisting myopathy or a myoneural disorder, since it may delay the recognition or confound the diagnosis of a drug-induced musculoskeletal effect. Patients should be advised to report promptly any unusual muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever. NRTI therapy should be interrupted if drug-related myopathy is suspected, and discontinued if myopathy is diagnosed.

References

  1. "Product Information. Retrovir (zidovudine)." Glaxo Wellcome, Research Triangle Park, NC.
  2. "Product Information. Tyzeka (telbivudine)." IDEC Pharmaceuticals Corporation, San Diego, CA.
Moderate

Telbivudine (Includes Telbivudine) ↔ Hemodialysis

Moderate Potential Hazard, High plausibility

Applies to: hemodialysis

Telbivudine is removed by hemodialysis. Up to four hours of hemodialysis can reduce systemic telbivudine exposure by approximately 23%. Telbivudine should be administered after hemodialysis. Following dose interval adjustment for creatinine clearance, no additional dose modification is necessary during routine hemodialysis.

References

  1. "Product Information. Tyzeka (telbivudine)." IDEC Pharmaceuticals Corporation, San Diego, CA.
Moderate

Telbivudine (Includes Telbivudine) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Telbivudine is primarily eliminated by the kidney. Compared to patients with normal renal function (CrCl above 80 mL/min), systemic exposure (AUC) of single-dose telbivudine increased by 26% in patients with moderate renal dysfunction (CrCl 30 to 49 mL/min) and 136% in patients with end-stage renal disease managed on hemodialysis. Renal clearance decreased by 66% and 91%, respectively, in patients with moderate and severe renal dysfunction (CrCl below 30 mL/min). Adjustment of the dosing interval is recommended for patients with CrCl below 50 mL/min, including patients on dialysis, in accordance with the manufacturer's product labeling.

References

  1. "Product Information. Tyzeka (telbivudine)." IDEC Pharmaceuticals Corporation, San Diego, CA.

telbivudine drug Interactions

There are 260 drug interactions with telbivudine

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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