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Sodium chloride Disease Interactions

There are 2 disease interactions with sodium chloride.


Sodium salts (applies to sodium chloride) sodium/water imbalance

Major Potential Hazard, High plausibility. Applicable conditions: Fluid Retention, Congestive Heart Failure, Hypokalemia

Sodium chloride can induce sodium and water retention and result in hypernatremia, hypokalemia, edema and aggravation of congestive heart failure. Therapy with sodium- containing agents should be administered with extreme caution, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states where there is edema with sodium retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with sodium- containing agents is recommended.


  1. "Product Information. Megace (megestrol)." Bristol-Myers Squibb (2001):
  2. "Product Information. Calcibind (cellulose sodium phosphate)." Mission Pharmacal Company (2001):
  3. "Product Information. Sodium Benzoate (sodium benzoate)." Taylor Pharmaceuticals (2001):

Sodium chloride (applies to sodium chloride) acidosis

Moderate Potential Hazard, Moderate plausibility.

Administration of excessive amounts of sodium chloride can increase chloride concentrations and cause a loss of bicarbonate that results in metabolic acidosis. Clinical monitoring of acid/base balance and electrolyte concentrations is recommended.


  1. "Product Information. Megace (megestrol)." Bristol-Myers Squibb (2001):

Sodium chloride drug interactions

There are 2 drug interactions with sodium chloride.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.