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Pneumococcal 23-polyvalent vaccine Disease Interactions

There are 2 disease interactions with pneumococcal 23-polyvalent vaccine.

Moderate

Pneumococcal 23 valent vaccine (applies to pneumococcal 23-polyvalent vaccine) cardiovascular disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Pulmonary Heart or Vascular Disease

Caution and appropriate monitoring should be exercised when administering pneumococcal 23 valent vaccine to individuals with severely compromised cardiovascular and/or pulmonary function in whom a systemic reaction would pose a significant risk.

References (1)
  1. (2022) "Product Information. Pneumovax 23 (pneumococcal 23-polyvalent vaccine)." Merck & Co., Inc
Moderate

Vaccines (inactivated)/toxoids (applies to pneumococcal 23-polyvalent vaccine) immunodeficiency

Moderate Potential Hazard, High plausibility.

The expected serum antibody responses may not be obtained when vaccines and/or toxoids are administered to patients with primary or acquired immunodeficiency, including those with severe combined immunodeficiency, hypogammaglobulinemia or agammaglobulinemia, HIV infection, altered immune states (due to diseases such as leukemia, lymphoma, or generalized malignancy), or immunosuppression due to drug or other treatments (e.g., corticosteroids, alkylating agents, antimetabolites, or radiation).

References (15)
  1. (2001) "Product Information. Tetanus Toxoid Adsorbed (tetanus vaccine)." Aventis Pharmaceuticals
  2. (2022) "Product Information. Typhim VI (typhoid vaccine, inactivated)." Apothecon Inc
  3. (2022) "Product Information. Pneumovax 23 (pneumococcal 23-polyvalent vaccine)." Merck & Co., Inc
  4. "Product Information. Fluzone (influenza virus vaccine, inactivated)." Connaught Laboratories Inc
  5. "Product Information. Omnihib (haemophilus b conjugate vaccine (obsolete))." SmithKline Beecham
  6. "Product Information. Menomune A/C/Y/W-135 (meningococcal polysaccharide vaccine)." Connaught Laboratories Inc
  7. (2001) "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc
  8. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. (1997) "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics
  9. "Product Information. Havrix (HepA) (hepatitis A adult vaccine)." SmithKline Beecham
  10. (2022) "Product Information. Engerix-B (HepB) (hepatitis B adult vaccine)." Apothecon Inc
  11. (2006) "Product Information. Gardasil (human papillomavirus vaccine)." Merck & Co., Inc
  12. (2009) "Product Information. Cervarix (human papillomavirus vaccine)." GlaxoSmithKline
  13. (2022) "Product Information. Prevnar 13 (pneumococcal 13-valent conjugate vaccine)." Apothecon Inc
  14. (2016) "Product Information. Gardasil 9 (human papillomavirus vaccine)." Merck & Co., Inc
  15. (2025) "Product Information. Vimkunya Prefilled Syringe (cvx 329) (chikungunya vaccine, recombinant (cvx 329))." Bavarian Nordic, Inc.

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Pneumococcal 23-polyvalent vaccine drug interactions

There are 304 drug interactions with pneumococcal 23-polyvalent vaccine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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