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Sandostatin LAR Depot (octreotide) Disease Interactions

There are 3 disease interactions with Sandostatin LAR Depot (octreotide):


Octreotide (Includes Sandostatin LAR Depot) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Octreotide is eliminated by the kidney. Approximately 30% of octreotide is excreted unchanged in the urine. The serum concentration of octreotide and the half-life is increased in patients with severe renal dysfunction. Therapy with octreotide should be administered cautiously and dosage modification considered in patients with severe renal impairment as the half-life of octreotide may be increased, necessitating adjustment of the dosage.


  1. "Product Information. Sandostatin (octreotide)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

Octreotide (Includes Sandostatin LAR Depot) ↔ Heart Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Heart Disease

Bradycardia, arrhythmias and conduction abnormalities, including QT prolongation have been reported with the use of octreotide. Patients taking other drugs that have bradycardic effects may need dose adjustments. Caution is recommended in patients with cardiac function abnormalities.


Octreotide (Includes Sandostatin LAR Depot) ↔ Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The half-life of octreotide may be increased in patients with liver cirrhosis, necessitating adjustment of dosage. This dose should be up titrated based on clinical response and speed of response as deemed necessary by the physician.

Sandostatin LAR Depot (octreotide) drug Interactions

There are 167 drug interactions with Sandostatin LAR Depot (octreotide)

Sandostatin LAR Depot (octreotide) alcohol/food Interactions

There is 1 alcohol/food interaction with Sandostatin LAR Depot (octreotide)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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