Gomekli Disease Interactions
There are 4 disease interactions with Gomekli (mirdametinib).
Mirdametinib (applies to Gomekli) cardiac disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease, Cardiovascular Disease
Mirdametinib can cause left ventricular dysfunction (LVEF) and has not been studied in patients with a history of clinically significant cardiac disease or LVEF.
Mirdametinib (applies to Gomekli) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Mirdametinib has not been studied in patients with moderate or severe liver dysfunction. No dose adjustment is recommended in patients with mild liver dysfunction.
Mirdametinib (applies to Gomekli) ocular toxicity
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Visual Defect/Disturbance
Mirdametinib can cause ocular toxicity including retinal vein occlusion (RVO), retinal pigment epithelium detachment (RPED), and blurred vision. A comprehensive ophthalmic assessment prior to initiating treatment, and at regular intervals during treatment is recommended.
Mirdametinib (applies to Gomekli) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Mirdametinib has not been studied in patients with severe renal dysfunction. No dose adjustment is recommended in patients with mild or moderate renal dysfunction.
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Gomekli drug interactions
There are 11 drug interactions with Gomekli (mirdametinib).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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