Zokinvy Disease Interactions
There are 2 disease interactions with Zokinvy (lonafarnib).
Lonafarnib (applies to Zokinvy) hepatic dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Hepatic transaminase elevations (i.e., aspartate aminotransferase AST] and alanine aminotransferase ([ALT]) have been reported during lonafarnib therapy. Often these elevations improve with continued therapy, but it is not possible to exclude this drug as a cause of the abnormalities. Liver enzymes should be monitored periodically during therapy.
Lonafarnib (applies to Zokinvy) nephrotoxicity
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Lonafarnib has not been studied in patients with renal impairment, however, this drug caused nephrotoxicity in rats at plasma drug exposures approximately equal to that achieved with the human dose. Renal function should be monitored at regular intervals during therapy.
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Zokinvy drug interactions
There are 528 drug interactions with Zokinvy (lonafarnib).
Zokinvy alcohol/food interactions
There is 1 alcohol/food interaction with Zokinvy (lonafarnib).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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