Recorlev Disease Interactions
There are 3 disease interactions with Recorlev (levoketoconazole).
Levoketoconazole (applies to Recorlev) liver impairment/hepatotoxicity
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Levoketoconazole has been associated with serious hepatotoxicity and it is contraindicated in patients with cirrhosis, acute liver disease or poorly controlled chronic liver disease, baseline AST or ALT > 3 times the upper limit of normal, recurrent symptomatic cholelithiasis, a prior history of drug induced liver injury due to ketoconazole or any azole antifungal therapy that required discontinuation of treatment, or extensive metastatic liver disease.
Levoketoconazole (applies to Recorlev) QT prolongation
Major Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias
Levoketoconazole is associated with dose-related QT interval prolongation which may result in life-threatening ventricular dysrhythmias such as torsades de pointes. This drug is contraindicated in patients with prolonged QTcF interval > 470 msec at baseline, history of torsades de pointes, ventricular tachycardia, ventricular fibrillation, or prolonged QT syndrome. Patients receiving treatment should be monitored with an ECG prior to and during treatment.
Levoketoconazole (applies to Recorlev) hypokalemia/hypomagnesemia
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Magnesium Imbalance
Electrolyte imbalances such as hypokalemia and hypomagnesemia must be treated and corrected before starting treatment with levoketoconazole.
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Recorlev drug interactions
There are 854 drug interactions with Recorlev (levoketoconazole).
Recorlev alcohol/food interactions
There is 1 alcohol/food interaction with Recorlev (levoketoconazole).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.