Lesinurad Disease Interactions
There are 4 disease interactions with lesinurad:
Antihyperuricemic agents (Includes lesinurad) ↔ secondary hyperuricemia
Severe Potential Hazard, Moderate plausibility. Applies to: Tumor Lysis Syndrome, Lesch-Nyhan Syndrome, Organ Transplant
No studies with febuxostat or lesinurad have been conducted in patients with secondary hyperuricemia (including organ transplant recipients). The use of these drugs is contraindicated in patients where the uric acid formation is greatly increased, such as patients with malignant disease, tumor lysis syndrome or Lesch-Nyhan syndrome.
Lesinurad (Includes lesinurad) ↔ severe renal impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Kidney Transplant, Renal Dysfunction
The use of lesinurad is contraindicated in patients with severe renal impairment, end stage renal disease, kidney transplant recipient and patients on dialysis.
Antihyperuricemic agents (Includes lesinurad) ↔ CV disease
Moderate Potential Hazard, Moderate plausibility. Applies to: Cardiovascular Disease
Major adverse cardiovascular events (cardiovascular deaths, non- fatal myocardial infarctions and non- fatal strokes), were reported during clinical trials with some antihyperuricemic agents, such as febuxostat and lesinurad. Although a causal relationship has not been established, caution is advised when used in patients with cardiovascular disease. Monitoring for signs or symptoms of myocardial infarction or stroke is recommended.
Febuxostat/lesinurad (Includes lesinurad) ↔ hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
No studies have been conducted in patients with severe hepatic impairment (Child-Pugh Class C), therefore caution should be exercised if using febuxostat or lesinurad on these patients. No dose adjustment is necessary in patients with mild or moderate hepatic impairment.
Lesinurad drug interactions
There are 273 drug interactions with lesinurad
More about lesinurad
- Lesinurad Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 2 Reviews
- Drug class: antihyperuricemic agents
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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