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Camptosar (irinotecan) Disease Interactions

There is 1 disease interaction with Camptosar (irinotecan):


Irinotecan (Includes Camptosar) ↔ myelosuppression

Severe Potential Hazard, High plausibility. Applies to: Bleeding, Bone Marrow Depression/Low Blood Counts

Irinotecan induces myelosuppression, causing leukopenia and anemia. Deaths due to sepsis following severe neutropenia have been reported in patients treated with irinotecan. Hold irinotecan if neutropenic fever occurs or if the absolute neutrophil count drops <1000/mm3. After recovery to an absolute neutrophil count =1000/mm3, subsequent doses of irinotecan should be reduced. Therapy with irinotecan should be administered cautiously in patients who have received previous irradiation therapy. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Close clinical monitoring of hematopoietic function is recommended.


  1. "Product Information. Camptosar (irinotecan)." Pharmacia and Upjohn, Kalamazoo, MI.

Camptosar (irinotecan) drug interactions

There are 433 drug interactions with Camptosar (irinotecan)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.