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Human papillomavirus vaccine Disease Interactions

There are 3 disease interactions with human papillomavirus vaccine.

Major

Vaccination (applies to human papillomavirus vaccine) infections

Major Potential Hazard, High plausibility. Applicable conditions: Fever, Infection - Bacterial/Fungal/Protozoal/Viral

Ideally, vaccination should occur when an individual is healthy, thus minimizing the risk of an adverse host reaction and/or vaccine failure. However, a current or recent infection does not necessarily preclude the use of vaccines, depending on the severity of the patient's symptoms and their etiology. Superficial infections and minor acute illnesses such as a mild upper respiratory infection with or without low-grade fever do not contraindicate immunization, particularly if prompt administration of a vaccine is deemed necessary or beneficial. In fact, when vaccines are administered during the course of a minor illness, the risk of adverse events is not increased, and serum antibody response is not often diminished. On the other hand, if fever or symptoms suggest a moderate or severe illness, it is usually appropriate to withhold vaccination until the patient has recovered. In addition to the potential risks already mentioned, evolving signs and symptoms of the illness can sometimes confound the diagnosis of a vaccine reaction if it develops. In the presence of any infection, the decision to administer or withhold/defer immunization should take into consideration the benefits versus the risks to an individual patient.

References

  1. "Product Information. Typhim VI (typhoid vaccine, inactivated)." Apothecon Inc (2022):
  2. "Product Information. Varivax (varicella virus vaccine)." Merck & Company Inc (2022):
  3. "Product Information. Pneumovax 23 (pneumococcal 23-polyvalent vaccine)." Merck & Company Inc (2022):
  4. "Product Information. Mumpsvax (mumps virus vaccine)." Merck & Company Inc (2022):
  5. "Product Information. Meruvax II (rubella virus vaccine)." Merck & Company Inc (2022):
  6. "Product Information. Attenuvax (measles virus vaccine)." Merck & Company Inc (2022):
  7. "Product Information. Orimune (poliovirus vaccine, live, trivalent)." Lederle Laboratories (2022):
  8. "Product Information. YF-Vax (yellow fever vaccine)." sanofi pasteur (2001):
  9. "Product Information. Omnihib (haemophilus b conjugate vaccine)." SmithKline Beecham, Philadelphia, PA.
  10. "Product Information. Menomune-A/C/Y/W-135 (meningococcal polysaccharide vaccine)." Connaught, Swiftwater, PA.
  11. "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc (2001):
  12. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics (1997):
  13. "Product Information. Cholera vaccine (cholera vaccine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  14. "Product Information. Havrix (hepatitis A vaccine)." SmithKline Beecham, Philadelphia, PA.
  15. "Product Information. Engerix-B (hepatitis B adult vaccine)." Apothecon Inc (2022):
  16. "Product Information. Zostavax (zoster vaccine live)." Merck & Company Inc (2006):
  17. "Product Information. Gardasil (human papillomavirus vaccine)." Merck & Company Inc (2006):
  18. "Product Information. Gardasil 9 (human papillomavirus vaccine)." Merck & Company Inc (2016):
View all 18 references
Moderate

Human papillomavirus (applies to human papillomavirus vaccine) syncope

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Dehydration, Hypotension

The administration of human papillomavirus vaccine has been associated with syncope, sometimes resulting in falling with injury. The syncope sometimes is associated with tonic-clonic movements and other seizure-like activity. Caution is recommended when administering the vaccine to individuals susceptible to syncope. Observation for 15 minutes is recommended after its administration.

References

  1. "Product Information. Gardasil (human papillomavirus vaccine)." Merck & Company Inc (2006):
  2. "Product Information. Gardasil 9 (human papillomavirus vaccine)." Merck & Company Inc (2016):
Moderate

Vaccines (inactivated)/toxoids (applies to human papillomavirus vaccine) immunodeficiency

Moderate Potential Hazard, High plausibility.

The expected serum antibody responses may not be obtained when vaccines and/or toxoids are administered to patients with primary or acquired immunodeficiency, including those with severe combined immunodeficiency, hypogammaglobulinemia or agammaglobulinemia, HIV infection, altered immune states (due to diseases such as leukemia, lymphoma, or generalized malignancy), or immunosuppression due to drug or other treatments (e.g., corticosteroids, alkylating agents, antimetabolites, or radiation).

References

  1. "Product Information. Tetanus Toxoid Adsorbed (tetanus toxoid)." Aventis Pharmaceuticals (2001):
  2. "Product Information. Typhim VI (typhoid vaccine, inactivated)." Apothecon Inc (2022):
  3. "Product Information. Pneumovax 23 (pneumococcal 23-polyvalent vaccine)." Merck & Company Inc (2022):
  4. "Product Information. Fluzone Influenza Vaccine (influenza virus vaccine)." Connaught, Swiftwater, PA.
  5. "Product Information. Omnihib (haemophilus b conjugate vaccine)." SmithKline Beecham, Philadelphia, PA.
  6. "Product Information. Menomune-A/C/Y/W-135 (meningococcal polysaccharide vaccine)." Connaught, Swiftwater, PA.
  7. "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc (2001):
  8. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics (1997):
  9. "Product Information. Havrix (hepatitis A vaccine)." SmithKline Beecham, Philadelphia, PA.
  10. "Product Information. Engerix-B (hepatitis B adult vaccine)." Apothecon Inc (2022):
  11. "Product Information. Gardasil (human papillomavirus vaccine)." Merck & Company Inc (2006):
  12. "Product Information. Cervarix (human papillomavirus vaccine)." GlaxoSmithKline (2009):
  13. "Product Information. Prevnar 13 (pneumococcal 13-valent conjugate vaccine)." Apothecon Inc (2022):
  14. "Product Information. Gardasil 9 (human papillomavirus vaccine)." Merck & Company Inc (2016):
View all 14 references

Human papillomavirus vaccine drug interactions

There are 247 drug interactions with human papillomavirus vaccine.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.