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Gadoversetamide Disease Interactions

There are 3 disease interactions with gadoversetamide:

Major

GBCAs (applies to gadoversetamide) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Hypertension, Diabetes Mellitus

Gadolinium- based contrast agents (GBCAs) such as gadopentetate dimeglumine, gadoteridol and gadodiamide are contraindicated in patients with chronic, severe kidney disease (glomerular filtration rate, GFR < 30 mL/min), or acute kidney injury. GBCAs increase the risk for nephrogenic systemic fibrosis (NSF) among patients with impaired elimination of the drugs. Their use should be avoided in these patients unless the diagnostic information is essential and not available with non- contrasted MRI or other modalities. NSF may result in fatal or debilitating fibrosis affecting the skin, muscle and internal organs. Caution is advised in patients at risk for chronically reduced renal function (age >60 years, hypertension or diabetes). Always estimate the glomerular filtration rate (GFR) through laboratory testing.

Moderate

Gadoversetamide (applies to gadoversetamide) seizures

Moderate Potential Hazard, Moderate plausibility.

Seizures have been reported during post-approval use of gadoversetamide. Although is not possible to reliably estimate their frequency or establish a causal relationship, caution is advised in patients with seizure disorders.

Moderate

GBCAs (applies to gadoversetamide) allergies

Moderate Potential Hazard, Moderate plausibility.

Severe and fatal hypersensitivity reactions including anaphylaxis have been observed with administration of gadolinium based contrast agents, including gadoteridol. Patients with a history of allergy, drug reactions or other hypersensitivity-like disorders should be closely observed during the procedure and for several hours after drug administration. If a reaction occurs, stop administering and immediately begin appropriate therapy including resuscitation.

Gadoversetamide drug interactions

There are 25 drug interactions with gadoversetamide

Gadoversetamide alcohol/food interactions

There is 1 alcohol/food interaction with gadoversetamide

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.