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Monurol (fosfomycin) Disease Interactions

There are 2 disease interactions with Monurol (fosfomycin):


Fosfomycin (Includes Monurol) ↔ Hemodialysis

Moderate Potential Hazard, High plausibility

Applies to: hemodialysis

Fosfomycin is removed by hemodialysis and should be administered after dialysis sessions.


  1. Bouchet JL, Quentin C, Albin H, Vincon G, Guillon J, Martin-Dupont P "Pharmacokinetics of fosfomycin in hemodialyzed patients." Clin Nephrol 23 (1985): 218-21
  2. "Product Information. Monurol (fosfomycin)." Forest Pharmaceuticals, St. Louis, MO.
  3. Fernandez Lastra C, Marino EL, Dominguez-Gil A, Tabernero JM, Grande Villoria J "Pharmacokinetics of phosphomycin during haemofiltration." Br J Clin Pharmacol 17 (1984): 477-80
  4. Dalet F, Bade G, Roda M "Pharmacokinetics of fosfomycin during hemodialysis." Chemotherapy 23(suppl 1 (1977): 210-6
  5. Revert L, Lopez J, Pons J, Olay T "Fosfomycin in patients subjected to periodic hemodialysis." Chemotherapy 23(suppl 1 (1977): 204-9
View all 5 references

Fosfomycin (Includes Monurol) ↔ Renal Dysfunction

Minor Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Fosfomycin is eliminated unchanged by the kidney (38%) and in the feces (18%). The excretion of fosfomycin is significantly decreased and the half-life prolonged in patients with compromised renal function. Side effects (e.g., diarrhea, headache, nausea, vaginitis) may be prolonged in patients with renal impairment.


  1. Gobernado M, Garcia J, Santos M, Panadero J, Diosdado N "Renal insufficiency and fosfomycin." Chemotherapy 23(suppl 1 (1977): 200-3
  2. "Product Information. Monurol (fosfomycin)." Forest Pharmaceuticals, St. Louis, MO.

Monurol (fosfomycin) drug Interactions

There are 3 drug interactions with Monurol (fosfomycin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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