Monurol (fosfomycin) Disease Interactions
There are 2 disease interactions with Monurol (fosfomycin):
Fosfomycin (Includes Monurol) ↔ Hemodialysis
Moderate Potential Hazard, High plausibility
Applies to: hemodialysis
Fosfomycin is removed by hemodialysis and should be administered after dialysis sessions.
- Bouchet JL, Quentin C, Albin H, Vincon G, Guillon J, Martin-Dupont P "Pharmacokinetics of fosfomycin in hemodialyzed patients." Clin Nephrol 23 (1985): 218-21
- Dalet F, Bade G, Roda M "Pharmacokinetics of fosfomycin during hemodialysis." Chemotherapy 23(suppl 1 (1977): 210-6
- Revert L, Lopez J, Pons J, Olay T "Fosfomycin in patients subjected to periodic hemodialysis." Chemotherapy 23(suppl 1 (1977): 204-9
Fosfomycin (Includes Monurol) ↔ Renal Dysfunction
Minor Potential Hazard, Moderate plausibility
Applies to: Renal Dysfunction
Fosfomycin is eliminated unchanged by the kidney (38%) and in the feces (18%). The excretion of fosfomycin is significantly decreased and the half-life prolonged in patients with compromised renal function. Side effects (e.g., diarrhea, headache, nausea, vaginitis) may be prolonged in patients with renal impairment.
- Gobernado M, Garcia J, Santos M, Panadero J, Diosdado N "Renal insufficiency and fosfomycin." Chemotherapy 23(suppl 1 (1977): 200-3
- "Product Information. Monurol (fosfomycin)." Forest Pharmaceuticals, St. Louis, MO.
Monurol (fosfomycin) drug Interactions
There are 3 drug interactions with Monurol (fosfomycin)
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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