Ferumoxides Disease Interactions

The possibility of a reaction including serious, life-threatening, fatal, anaphylactoid or cardiovascular reactions should always be considered when using ferumoxides. Increased risk is associated with a known sensitivity to iron or dextran, history of previous reaction to a radiographic contrast agent, known allergies, other hypersensitivities, and underlying immune disorders, autoimmunity or immunodeficiencies that predispose to specific or non specific mediator release.

Ferumoxides has not been studied in patients with immune disease, but a high rate of adverse reactions to injectable iron formulations have been reported in the published literature. Caution is advised.

Ferumoxides which contains iron, should be used with caution in patients with disorders associated with iron over load (e.g., hemosiderosis, chronic hemolytic anemia with frequent blood transfusions).