Enfortumab vedotin Disease Interactions

Avoid the use of enfortumab vedotin in patients with moderate or severe hepatic impairment as it has not been studied in these patients. No adjustment in the starting dose is required when treating patients with mild hepatic impairment.

Hyperglycemia occurred in patients treated with enfortumab vedotin, including death, and diabetic ketoacidosis (DKA) in those with and without preexisting-existing diabetes mellitus. The incidence of Grade 3-4 hyperglycemia increased consistently in patients with higher body mass index and in patients with higher baseline A1C. Closely monitor blood glucose levels in patients with, or at risk for, diabetes mellitus or hyperglycemia. If blood glucose is elevated (>250 mg/dL), withhold treatment.

Peripheral neuropathy, predominantly sensory, occurred in 49% of the patients treated with enfortumab vedotin in clinical trials. Peripheral neuropathy occurred in patients with or without preexisting peripheral neuropathy. Monitor patients for symptoms of new or worsening peripheral neuropathy and consider dose interruption or dose reduction when peripheral neuropathy occurs. Permanently discontinue treatment in patients that develop Grade >3 peripheral neuropathy.