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Skysona Disease Interactions

There are 4 disease interactions with Skysona (elivaldogene autotemcel).

Major

Elivaldogene autotemcel (applies to Skysona) infections

Major Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral

Severe infections, including fatal infections have occurred in patients after infusion with elivaldogene autotemcel. Patients should be monitored for infection before and during treatment, and prophylactic antimicrobials may need to be administered according to clinical guidelines. Administration of elivaldogene autotemcel should be avoided in patients with active infections.

Moderate

Elivaldogene autotemcel (applies to Skysona) HIV

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: HIV Infection

Elivaldogene autotemcel has not been studied in patients with HIV. A negative serology test for HIV is necessary before the collection of cells, to ensure acceptance of apheresis material for elivaldogene autotemcel manufacturing. Material for patients with a positive HIV test, will not be accepted for manufacturing.

Moderate

Elivaldogene autotemcel (applies to Skysona) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Elivaldogene autotemcel has not been studied in patients with hepatic impairment. Patients should be assessed for hepatic impairment to ensure that hematopoietic stem cell (HSC) transplantation is appropriate.

Moderate

Elivaldogene autotemcel (applies to Skysona) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Elivaldogene autotemcel has not been studied in patients with renal impairment. Patients should be assessed for renal impairment, to ensure that hematopoietic stem cell (HSC) transplantation is appropriate.

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Skysona drug interactions

There are 130 drug interactions with Skysona (elivaldogene autotemcel).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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