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Prepidil Disease Interactions

There are 3 disease interactions with Prepidil (dinoprostone topical).

Moderate

Dinoprostone topical (applies to Prepidil) asthma

Moderate Potential Hazard, Moderate plausibility.

The use of dinoprostone may be associated with bronchospasm, decreased pulmonary blood flow, and/or increased pulmonary arterial pressure. Dinoprostone induces contraction of smooth muscle, including smooth muscle of the respiratory tract. Therapy with dinoprostone should be administered cautiously in patients with asthma, or history of childhood asthma, even in the absence of asthma attacks in adulthood.

References (2)
  1. (2022) "Product Information. Prostin E2 (dinoprostone topical)." Apothecon Inc
  2. (2001) "Product Information. Prepidil (dinoprostone topical)." Pharmacia and Upjohn
Moderate

Dinoprostone topical (applies to Prepidil) hypotension

Moderate Potential Hazard, High plausibility.

Therapy with dinoprostone should be administered cautiously in patients with a history of hypotension.

References (1)
  1. (2001) "Product Information. Prepidil (dinoprostone topical)." Pharmacia and Upjohn
Moderate

Dinoprostone topical glaucoma

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension

Caution should be exercised when administering dinoprostone topical in patients with a history of glaucoma.

References (1)
  1. (2001) "Product Information. Prepidil (dinoprostone topical)." Pharmacia and Upjohn

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Prepidil drug interactions

There are 6 drug interactions with Prepidil (dinoprostone topical).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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