Macrodex Disease Interactions
There are 4 disease interactions with Macrodex (dextran, high molecular weight).
Dextran (applies to Macrodex) cardiac failure
Major Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease
Low molecular weight and high molecular weight dextran is contraindicated in patients with marked cardiac decompensation.
References (1)
- (2013) "Product Information. Dextran In Dextrose (dextran, low molecular weight)." B Braun Medical Inc
Dextran (applies to Macrodex) hemostatic defects
Major Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect, Thrombocytopenia
The use of dextran is contraindicated in patients with marked hemostatic defects of all types (thrombocytopenia, hypofibrinogenemia, etc.) including those caused by drugs such as heparin, warfarin, etc.
References (1)
- (2013) "Product Information. Dextran In Dextrose (dextran, low molecular weight)." B Braun Medical Inc
Dextran (applies to Macrodex) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Low molecular and high molecular weight dextran are contraindicated in patients with renal disease with severe oliguria or anuria.
References (1)
- (2013) "Product Information. Dextran In Dextrose (dextran, low molecular weight)." B Braun Medical Inc
Dextran (applies to Macrodex) bleeding
Moderate Potential Hazard, Moderate plausibility.
Caution should be employed when using dextran (low and high molecular weight) in patients with active hemorrhage as the resulting increase in perfusion pressure and improved microcirculatory flow may result in additional blood loss.
References (1)
- (2013) "Product Information. Dextran In Dextrose (dextran, low molecular weight)." B Braun Medical Inc
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Macrodex drug interactions
There are 32 drug interactions with Macrodex (dextran, high molecular weight).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.