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Harmonyl Disease Interactions

There are 5 disease interactions with Harmonyl (deserpidine).

Major

Rauwolfia alkaloids (applies to Harmonyl) depression

Major Potential Hazard, High plausibility.

The use of rauwolfia alkaloids is contraindicated in patients with a history of mental depression, especially suicidal tendencies. Rauwolfia alkaloids depletes catecholamine and serotonin stores.

References (5)
  1. Fleishman M (1975) "Letter: Reserpine, ECT, and depression." Am J Psychiatry, 132, p. 1088
  2. Lewis WH (1971) "Iatrogenic psychotic depressive reaction in hypertensive patients." Am J Psychiatry, 127, p. 1416-7
  3. Ambrosino SV (1974) "Depressive reactions associated with reserpine." N Y State J Med, 74, p. 860-4
  4. Goodwin FK, Bunney WE, Jr (1971) "Depressions following reserpine: a reevaluation." Semin Psychiatry, 3, p. 435-48
  5. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Major

Rauwolfia alkaloids (applies to Harmonyl) PUD/ulcerative colitis

Major Potential Hazard, High plausibility. Applicable conditions: Peptic Ulcer, Inflammatory Bowel Disease

The use of rauwolfia alkaloids is contraindicated in patients with active peptic ulcer or ulcerative colitis. Since rauwolfia alkaloids increase gastrointestinal motility and secretion, these conditions may be aggravated. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of peptic ulcer or ulcerative colitis because of the risk of reactivation.

References (1)
  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Moderate

Antiadrenergic (peripheral) (applies to Harmonyl) peripheral edema

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Fluid Retention

Peripheral- acting antiadrenergic agents can cause peripheral edema. Therapy with peripheral- acting antiadrenergic agents should be administered cautiously in patients adversely affected by sodium and water retention.

References (7)
  1. Weil JV, Chidsey CA (1968) "Plasma volume expansion resulting from interference with adrenergic function in normal man." Circulation, 37, p. 54-61
  2. (1977) "Prazosin (Minipress) for hypertension." Med Lett Drugs Ther, 19, p. 1-2
  3. (2001) "Product Information. Cardura (doxazosin)." Pfizer U.S. Pharmaceuticals
  4. (2001) "Product Information. Hytrin (terazosin)." Abbott Pharmaceutical
  5. (2001) "Product Information. Ismelin (guanethidine)." Ciba-Geigy Pharmaceuticals
  6. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
  7. (2001) "Product Information. Hylorel (guanadrel)." Rhone Poulenc Rorer
Moderate

Rauwolfia alkaloids (applies to Harmonyl) biliary colic

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cholelithiasis

Rauwolfia alkaloids increase gastrointestinal motility and secretion and can precipitate biliary colic in patients with gallstones. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of gallstones.

References (1)
  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Moderate

Rauwolfia alkaloids (applies to Harmonyl) renal dysfunction

Moderate Potential Hazard, High plausibility.

In general, lowering the blood pressure may cause some decrease in renal function. Therefore, rauwolfia alkaloids should be used with caution in patients with renal impairment, since these patients may adjust poorly to the hypotensive effects of these agents.

References (1)
  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

Switch to consumer interaction data

Harmonyl drug interactions

There are 252 drug interactions with Harmonyl (deserpidine).

Harmonyl alcohol/food interactions

There is 1 alcohol/food interaction with Harmonyl (deserpidine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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