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Nesacaine Disease Interactions

There are 7 disease interactions with Nesacaine (chloroprocaine).

Major

Chloroprocaine (applies to Nesacaine) neuro/spinal

Major Potential Hazard, Moderate plausibility. Applicable conditions: Neurologic Disorder, Scoliosis, Hypertension, Sepsis

Lumbar and caudal epidural anesthesia should be used with extreme caution in persons with neurological disease, spinal deformities, septicemia, and severe hypertension.

Moderate

Chloroprocaine (applies to Nesacaine) CV disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease

Local anesthetics such as chloroprocaine should be used with caution in patients with impaired cardiovascular function since they may be less able to compensate for functional changes associated with the prolongation of A-V conduction produced by these drugs.

Moderate

Chloroprocaine (applies to Nesacaine) hypertensive vascular disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Hypertension, Peripheral Arterial Disease

Local anesthetic injections containing a vasoconstrictor should be used cautiously and in carefully circumscribed quantities in areas of the body supplied by end arteries or having otherwise compromised blood supply. Patients with peripheral vascular disease and those with hypertensive vascular disease may exhibit exaggerated vasoconstrictor response. Ischemic injury or necrosis may result. Caution is advised.

Moderate

Chloroprocaine (applies to Nesacaine) hypotension

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Block

Local anesthetics such as chloroprocaine, should be used with caution in patients with hypotension or heart block.

Moderate

Chloroprocaine (applies to Nesacaine) liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Since ester-type local anesthetics like chloroprocaine are hydrolyzed by plasma cholinesterase produced by the liver, chloroprocaine should be used cautiously in patients with hepatic disease.

Moderate

Chloroprocaine (applies to Nesacaine) methemoglobinemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency, Heart Disease

Cases of methemoglobinemia have been reported in association with local anesthetic use such as chloroprocaine. Although all patients are at risk for methemoglobinemia, patients with glucose- 6-phosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months of age, and concurrent exposure to oxidizing agents or their metabolites are more susceptible to developing clinical manifestations of the condition. If local anesthetics must be used in these patients, close monitoring for symptoms and signs of methemoglobinemia is recommended.

Moderate

Chloroprocaine (applies to Nesacaine) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Chloroprocaine and its metabolites are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. The elderly and patients with decreased renal function, might need cautious dose selection and renal function monitoring.

Nesacaine drug interactions

There are 94 drug interactions with Nesacaine (chloroprocaine).

Nesacaine alcohol/food interactions

There are 2 alcohol/food interactions with Nesacaine (chloroprocaine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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