Generic name: Chloroprocaine Hydrochloride 10mg in 1mL
Dosage form: injection, solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Chloroprocaine may be administered as a single injection or continuously through an indwelling catheter. As with all local
anesthetics, the dose administered varies with the anesthetic procedure, the vascularity of the tissues, the depth of anesthesia and
degree of muscle relaxation required, the duration of anesthesia desired, and the physical condition of the patient. The smallest
dose and concentration required to produce the desired result should be used. Dosage should be reduced for children, elderly and debilitated patients and patients with cardiac and/or liver disease. The maximum single recommended doses of chloroprocaine in adults are: without epinephrine, 11 mg/kg, not to exceed a maximum total dose of 800 mg; with epinephrine (1:200,000), 14 mg/kg, not to exceed a maximum total dose of 1000 mg. For specific techniques and procedures, refer to standard textbooks.
There have been adverse event reports of chondrolysis in patients receiving intra-articular infusions of local anesthetics following
arthroscopic and other surgical procedures. Nesacaine is not approved for this use (see WARNINGS and DOSAGE AND
Caudal and Lumbar Epidural Block: In order to guard against adverse experiences sometimes noted following unintended
penetration of the subarachnoid space, the following procedure modifications are recommended:
1. Use an adequate test dose (3 mL of Nesacaine-MPF 3% Injection or 5 mL of Nesacaine-MPF 2% Injection) prior to induction
of complete block. This test dose should be repeated if the patient is moved in such a fashion as to have displaced the epidural
catheter. Allow adequate time for onset of anesthesia following administration of each test dose.
2. Avoid the rapid injection of a large volume of local anesthetic injection through the catheter. Consider fractional doses, when
3. In the event of the known injection of a large volume of local anesthetic injection into the subarachnoid space, after suitable
resuscitation and if the catheter is in place, consider attempting the recovery of drug by draining a moderate amount of
cerebrospinal fluid (such as 10 mL) through the epidural catheter.
As a guide for some routine procedures, suggested doses are given below:
1. Infiltration and Peripheral Nerve Block: NESACAINE or NESACAINE-MPF (chloroprocaine HCl Injection, USP)
2. Caudal and Lumbar Epidural Block: NESACAINE-MPF INJECTION.
For caudal anesthesia, the initial dose is 15 to 25 mL of a 2% or 3% solution. Repeated doses may be given at 40 to 60 minute
For lumbar epidural anesthesia, 2 to 2.5 mL per segment of a 2% or 3% solution can be used. The usual total volume of
Nesacaine-MPF Injection is from 15 to 25 mL. Repeated doses 2 to 6 mL less than the original dose may be given at 40 to 50 minute
The above dosages are recommended as a guide for use in the average adult. Maximum dosages of all local anesthetics must be
individualized after evaluating the size and physical condition of the patient and the rate of systemic absorption from a particular
Pediatric Dosage: It is difficult to recommend a maximum dose of any drug for children, since this varies as a function of age and
weight. For children over 3 years of age who have a normal lean body mass and normal body development, the maximum dose is
determined by the child’s age and weight and should not exceed 11 mg/kg (5 mg/lb). For example, in a child of 5 years weighing
50 lbs (23 kg), the dose of chloroprocaine HCl without epinephrine would be 250 mg. Concentrations of 0.5–1% are suggested for
infiltration and 1–1.5% for nerve block. In order to guard against systemic toxicity, the lowest effective concentration and lowest
effective dose should be used at all times. Some of the lower concentrations for use in infants and smaller children are not available
in prepackaged containers; it will be necessary to dilute available concentrations with the amount of 0.9% sodium chloride injection
necessary to obtain the required final concentration of chloroprocaine injection.
Preparation of Epinephrine Injections—To prepare a 1:200,000 epinephrine-chloroprocaine HCl injection, add 0.1 mL of a 1 to
1000 Epinephrine Injection USP to 20 mL of Nesacaine-MPF Injection.
Chloroprocaine is incompatible with caustic alkalis and their carbonates, soaps, silver salts, iodine and iodides.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever
injection and container permit. As with other anesthetics having a free aromatic amino group, Nesacaine and Nesacaine-MPF
Injections are slightly photosensitive and may become discolored after prolonged exposure to light. It is recommended that these vials
be stored in the original outer containers, protected from direct sunlight. Discolored injection should not be administered. If exposed
to low temperatures, Nesacaine and Nesacaine-MPF Injections may deposit crystals of chloroprocaine HCl which will redissolve with
shaking when returned to room temperature. The product should not be used if it contains undissolved (eg, particulate) material.