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Vyleesi Disease Interactions

There are 3 disease interactions with Vyleesi (bremelanotide).

Major

Bremelanotide (applies to Vyleesi) hypertension/CV disease

Major Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease

Bremelanotide is contraindicated in patients who have uncontrolled hypertension or known cardiovascular disease, as it transiently increases blood pressure and reduces heart rate after each dose. Before initiating bremelanotide, and periodically during treatment, consider the patient's cardiovascular risk and ensure blood pressure is well-controlled.

References

  1. (2019) "Product Information. Vyleesi (bremelanotide)." AMAG Pharmaceuticals Inc
Moderate

Bremelanotide (applies to Vyleesi) severe hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Bremelanotide has not been evaluated in patients with severe hepatic impairment and should be used with caution in these patients (Child-Pugh C; score 10-15), because they may have an increase in the incidence and severity of adverse reactions (e.g., nausea and vomiting). No dosing adjustments are recommended for patients with mild to moderate (Child-Pugh A and B; score 5-9) hepatic impairment.

References

  1. (2019) "Product Information. Vyleesi (bremelanotide)." AMAG Pharmaceuticals Inc
Moderate

Bremelanotide (applies to Vyleesi) severe renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Use bremelanotide with caution in patients with severe (eGFR <30 mL/min/1.73 m2) renal impairment, because these patients may have an increase in the incidence and severity of adverse reactions (e.g., nausea and vomiting). No dosing adjustments are recommended for patients with mild to moderate (eGFR 30-89 mL/min/1.73 m2) renal impairment.

References

  1. (2019) "Product Information. Vyleesi (bremelanotide)." AMAG Pharmaceuticals Inc

Vyleesi drug interactions

There is 1 drug interaction with Vyleesi (bremelanotide).

Vyleesi alcohol/food interactions

There are 2 alcohol/food interactions with Vyleesi (bremelanotide).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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