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Vyleesi User Reviews & Ratings

Vyleesi has an average rating of 7.8 out of 10 from a total of 25 reviews on Drugs.com. 71% of reviewers reported a positive experience, while 13% reported a negative experience.

Condition Avg. Rating Reviews Compare
Hypoactive Sexual Desire Disorder  
7.8
25 reviews for Hypoactive Sexual Desire Disorder 3 medications
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Reviews for Vyleesi

  • Yodeler
  • November 18, 2020

For Hypoactive Sexual Desire Disorder "I had a Vyleesi injection in my leg because my libido problems. I felt like I was going to puke but only for a few seconds. I waited 45 min then headed to my boyfriend's house. By the time I get to his house I was keen for some action! We did it for what felt like forever and I was on a never ending orgasm. This sex serum stayed in my system all night! He's asleep at 3am and I'm over here about to give him the best wake up call of his life. Take a little pain in the leg for some amazing pleasure."

9 / 10
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54 Report
  • RGano
  • Taken for less than 1 month
  • May 28, 2022

For Hypoactive Sexual Desire Disorder "I have been struggling with HSDD for years.. the thought of my husband touching me repulsed me. I tried Addyi, it didn’t work. I’ve tried everything. I tried Vyleesi tonight for the first time and I am so so relieved that it WORKED! Here’s my experience, I took it at 9:00pm, right away I was nauseas but it went away within a few minutes. About 15 minutes later I started to feel the need to stretch my whole body out and oh did it feel good. Over the next hour I was laying in bed, having these amazing stretch sessions just waiting to feel some tingly sensations of arousal. Well, around 10:45pm I had to pee so I went to the bathroom. When I wiped I felt a tingly sensation “down there”. When I got back in bed I told my husband, “ I think it’s starting to work, I have faith.”. He then proceeded to touch my body (which I usually hate) and it kick started everything! Sex felt better than I ever remember!"

10 / 10
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34 Report
  • leemick
  • Taken for less than 1 month
  • March 7, 2023

For Hypoactive Sexual Desire Disorder "I am a 49 yr old woman suffering from low libido for the past 5 years. I know every woman's body responds differently to medications so I paid no mind to the negative reviews that stated "Don't waste your money." I was desperate for help, not to mention my husband was also. I tried vylessi for the first time last week. I was surprised that I did not feel any nausea at all. I did, however, feel the need to stretch constantly once it kicked in. I read to wait 45 minutes and in reality, it took me personally 1.5 - 2 hours before I felt any effects. Once it kicked in, it was amazing. I had sensations I haven't felt since I was a teenager. It was worth the endless stretching. It did not keep me awake or put me to sleep as some reviews state. The effects lasted me about 12-18 hours (I woke up and was still feeling tingly down there) I will defiantly use it again."

10 / 10
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18 Report

Frequently asked questions

  • brinn
  • Taken for 1 to 6 months
  • October 19, 2022

For Hypoactive Sexual Desire Disorder "I have struggled with HSDD for a while due to sexual assault in my childhood. I know this isn't for people who have struggled with that, however, Addyi was not working and never worked for me. I have shot anxiety, so when I tell you I couldn't feel this at ALL. I really mean. I didn't even feel a pinch from the needle because it's just that small. Pros: - It works. - I actually WANTED to have fun with my husband instead of being annoyed that he was touching me. - It lasted for almost 3 days - there's not a definitive time frame that it lasts as everyone is different. - It arrived within ONE day. Cons: - The first dose will make you nauseated. Dramamine and Zofran didn't help at all."

10 / 10
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21 Report
  • Horn...
  • Taken for less than 1 month
  • April 4, 2022

For Hypoactive Sexual Desire Disorder "Guys. I’m 13 hours post injection and I cannot cross my legs without being turned on. I feel like it definitely did the job, but damn, I gotta work now. My only complaint is that it made me pretty nauseous and I randomly got heartburn. It didn’t hurt at all to inject."

8 / 10
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24 Report

Are you taking this medicine?

  • Ms Be...
  • Taken for 6 months to 1 year
  • September 1, 2023

For Hypoactive Sexual Desire Disorder "It DEFINITELY works. It’s been around globally for many years and is available in other countries for both women and men (not under the name Vyleesi, but as PT-141 - look it up). The needle is insignificant as it's so tiny you don’t even feel it at all. It does make some feel nauseous preliminarily for a short while (laying down helps) and this could make some overly sensitive types shy away from it. (The initial nausea goes away with repeat usage.) But once that subsides - look out! Its effects last up to 24 hours and can take up to 2-3 hours to really kick in. Many use it reliably for occasional sexual escapades. It’s pretty intense so I don’t use it every time I have sex. But when I do, it makes me feel EXACTLY like I did when I was in my teens and early 20s—super horny! It elicits that kind of state where your burning desire WILL override your inhibitions—repeatedly. ;-) Affects men the same way. Amazing stuff. Finally, an aphrodisiac that works."

10 / 10
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9 Report
  • Pam
  • Taken for less than 1 month
  • May 18, 2023

For Hypoactive Sexual Desire Disorder "I took this drug for the first time and I experienced all the side effects listed: stuffy nose, coughing, extreme nausea, flushing/chills, headache, fatigue and soar was at injection site. The symptoms lasted 8 hours. I took compazine for nausea and finally fell asleep. The next day the nausea was gone but I felt fatigued. I stayed in bed most of the following day. I will never use this drug again. My husband and I could not engage sexually because I was so sick from the side effects."

1 / 10
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11 Report
  • Brooke
  • Taken for less than 1 month
  • March 5, 2023

For Hypoactive Sexual Desire Disorder "I am coming up my golden years and as of 4 years ago my desire for physical touch by my husband repulsed me. I was desperate to get that desire back. I got a rx for vylessi and was a good candidate. Despite the side effects that were noted, I know everyone’s body responds differently so I was not concerned about that. I was expecting nausea from what I read but had no nausea at all. I read to take it 45 min before “the moment” when with me … took 2 hours. It started with the continual need to stretch and vulva sensitivity. After that I realized I had finally found a way to regain feeling there. The sensation lasted about 18 hours. Fell asleep fine on it. It did not keep me awake. I will defiantly continue using vlyessi. It has been a live saver."

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12 Report
  • Anonymous
  • Taken for less than 1 month
  • September 2, 2023

For Hypoactive Sexual Desire Disorder "I was very concerned about all of the negative reviews, but experienced none of these. I found that it does what it says! It was the first time in over 3 years that I actually enjoyed sex!! My husband and I always had a great sex life until I went through menopause. After I took the injection, I was good! I did take an anti-nausea drug before, not sure if that helped with side effects. I will continue to take this, a life-saving hope for my marriage!! Thanks"

10 / 10
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8 Report
  • Pretty...
  • Taken for less than 1 month
  • July 24, 2023

For Hypoactive Sexual Desire Disorder "So far, I have taken 1 injection. It didn't kick in after 45 minutes. I ended up going to bed, and when I woke up, it felt like it was working! It wasn't anything crazy or overwhelming, but it definitely worked. I did have a panic when I saw on my insurance portal that I was responsible for $1700!!!! I called the pharmacy, and she confirmed that the patient payment required was only $98 for a 1-month supply!!"

8 / 10
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8 Report
  • Alice
  • April 30, 2023

For Hypoactive Sexual Desire Disorder "I have tried this a few times off and on over the past 1-2 years. Everyone is unique. I do get nauseous and have zero appetite but not enough to keep me from going out. I’ve used it probably 5-6 times and it’s seems to work better and better. I’m 48, been married 27 years and my drive has decreased. This has made for increased and sensitivity. Sex has been really good. I’m not going to use it a ton but, for me, it does work"

9 / 10
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9 Report
  • Miche...
  • Taken for 1 to 6 months
  • August 28, 2023

For Hypoactive Sexual Desire Disorder "My husband and I had not had sex for over a year, since we had our 3rd child. The injection in my thigh did not hurt at all. I took it about two hours before bed, after which I felt slightly hot and nauseous for a few minutes. About an hour later I was feeling the need to stretch, but the stretching felt good. I also started getting quite aroused, almost like I was 18 again. We not only had sex for the first time in a year, I orgasmed more than I ever have before, and had the best night's sleep. I've now taken it twice more with the same effect. Vyleesi has changed my life. I read that men could also take it and it had the same effect."

10 / 10
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7 Report
  • Cbreezy
  • Taken for less than 1 month
  • January 21, 2024

For Hypoactive Sexual Desire Disorder "This medicine worked disturbingly well! I nervously took it with the nausea pill and started a relaxation routine right afterwards. I felt minimal nausea and waited anxiously for 2 hours before bed. I could feel the sensation, but it was easily ignored. However, I woke multiple times in the middle of the night with an insatiable sexual urge that had never occurred... It was undeniable and could not be ignored. Not only did it make for a fun night, but it continued throughout the next day. I'm so shocked by how well the medicine worked, and will plan carefully now to administer when there's more time to play."

10 / 10
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4 Report
  • Its...
  • Taken for 1 to 6 months
  • July 23, 2022

For Hypoactive Sexual Desire Disorder "I've tried it 4 times. I am not going to order again. My body hurt the next day from all the stretching I felt I needed. It did make me sensitive in my clitoris area almost too much so. But I also got a cough and vomited twice. So I'd say it didn't work the way I had hoped it would."

4 / 10
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11 Report
  • KrisNAz
  • Taken for 1 to 6 months
  • November 12, 2021

For Hypoactive Sexual Desire Disorder "Ok, my late 40s has been challenging with entering pre- menopause and lack of sex drive. I am on HRT and its helped a little with sex drive but not enough. I am single and dating. The NP at the hormone clinic wrote me this when I asked her to. Its expensive and insurance won't cover it but I qualified for some coupon for one supply which had 4 pens in it. Its easy to use- remove cap and press against your thigh or buttock and press down and hold for 10 secs. Ok now, the big question- does it work? Well first, I need to take this a good 3 to 4 hrs before sex not 20 or 30 mins. Major sensitivity in clitoral area for a good 24 hrs after so be prepared. Did it make me horny? Not really. I also tend to have trouble sleeping when I take this, its weird. Sooo overall I haven't noticed any real side effects and will likely order again though I'm not sure how I'm going to pay for it."

7 / 10
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10 Report
  • Anony...
  • Taken for less than 1 month
  • November 12, 2023

For Hypoactive Sexual Desire Disorder "Excellent response within 2 hours of injection. Felt horrible the rest of the day though - nausea and diarrhea. May have been a bug though. Only used it once so not sure. Honestly though, totally worth it for the response I got."

10 / 10
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3 Report
  • murphy
  • Taken for less than 1 month
  • August 13, 2020

For Hypoactive Sexual Desire Disorder "It did work quite well but caused a headache after an hour or so, which subsided after a couple of hours."

7 / 10
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36 Report
  • DCano
  • Taken for 1 to 6 months
  • September 23, 2020

For Hypoactive Sexual Desire Disorder "Every woman and possibly men should know about Vyleesi. Easy to use, results were more then we expected. Highly Recommend ."

10 / 10
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29 Report
  • likeb...
  • Taken for 1 to 6 months
  • November 11, 2020

For Hypoactive Sexual Desire Disorder "Really wanted to want it again like we were in our 20s before the stress of kids, money, and work piled up. It worked amazing. I was told a large number of people experience nausea but it was minor."

9 / 10
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26 Report
  • peter
  • Taken for 1 to 6 months
  • September 15, 2023

For Hypoactive Sexual Desire Disorder "Easy to use, results were more than we expected. Highly recommend. Thank you!"

10 / 10
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8 Report
  • Na2urai
  • Taken for less than 1 month
  • May 12, 2023

For Hypoactive Sexual Desire Disorder "Amazing. I felt alive and felt everything. It did not take effect the same day for me it hit me the next day. But I am not complaining. Way better than Addyi that med made me sick as a dog."

10 / 10
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9 Report
  • Anonymous
  • September 17, 2020

For Hypoactive Sexual Desire Disorder "A true lifesaver. Thank you!"

10 / 10
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21 Report
  • Tray
  • Taken for 1 to 6 months
  • November 13, 2020

For Hypoactive Sexual Desire Disorder "Vyleesi eoesn’t work at all, I’m 37 and really no libido and tried it twice it does absolutely nothing. No one has really figured out how to fix a woman’s libido yet"

1 / 10
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19 Report
  • Steph...
  • October 3, 2022

For Hypoactive Sexual Desire Disorder "Not worth the money. Does little to nothing. Not what you expect. Female hormonal issues will be unsolved… discouraged"

1 / 10
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7 Report
  • Doge
  • Taken for 1 to 6 months
  • October 7, 2021

For Hypoactive Sexual Desire Disorder "Works great for low desire but bad side affect was globus lump feeling and tickle/tingle in my throat for months then when I quit it all went away. ."

4 / 10
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5 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.