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Fero-Grad-500 Disease Interactions

There are 7 disease interactions with Fero-Grad-500 (ascorbic acid/ferrous sulfate).

Major

Ferrous salts (applies to Fero-Grad-500) hemoglobin abnormalities

Major Potential Hazard, High plausibility. Applicable conditions: Hemoglobinopathy, Blood Transfusion

There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.

References

  1. "Product Information. Infed (iron dextran)." Schein Pharmaceuticals Inc PROD
  2. "Product Information. Venofer (iron sucrose)." American Regent Laboratories Inc PROD (2001):
Moderate

Ascorbic acid (vitamin C) (applies to Fero-Grad-500) hemolysis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Acute hemolysis following administration of high doses of ascorbic acid in patients with glucose-6-phosphate deficiency (G6PD) has been reported. Ascorbic acid should be administered cautiously and dosages modified in patients with G6PD.

References

  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical PROD
Moderate

Ascorbic acid (vitamin C) (applies to Fero-Grad-500) kidney stones

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Nephrolithiasis

Large doses of ascorbic acid have lead to hyperoxaluria in 5% of patients. Ascorbic acid can acidify urine resulting in precipitation of urate, cystine, or oxalate stones. Ascorbic acid should be administered cautiously and dosages modified in patients predisposed to renal stones. Clinical monitoring of urinalysis for pH and crystal formation is recommended.

References

  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical PROD
Moderate

Ascorbic acid (vitamin C) (applies to Fero-Grad-500) sodium

Moderate Potential Hazard, Low plausibility. Applicable conditions: Hypernatremia, Hypertension

Ascorbic acid preparations contain sodium. The sodium content should be considered when used in patients with sodium restricted diets and conditions require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

References

  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical PROD
Moderate

Ferrous salts (applies to Fero-Grad-500) achlorhydria

Moderate Potential Hazard, Moderate plausibility.

Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.

References

  1. "Product Information. Feosol (ferrous sulfate)." SmithKline Beecham PROD
  2. "Product Information. Ferrous Gluconate (ferrous gluconate)." Paddock Laboratories Inc (2016):
Moderate

Ferrous salts (applies to Fero-Grad-500) gastrointestinal irritation

Moderate Potential Hazard, High plausibility. Applicable conditions: Colitis/Enteritis (Noninfectious), Peptic Ulcer

Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.

References

  1. "Product Information. Feosol (ferrous sulfate)." SmithKline Beecham PROD
  2. "Product Information. Ferrous Gluconate (ferrous gluconate)." Paddock Laboratories Inc (2016):
Minor

Ascorbic acid (vitamin C) (applies to Fero-Grad-500) dialysis

Minor Potential Hazard, High plausibility. Applicable conditions: hemodialysis

Ascorbic acid is removed by dialysis.

References

  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical PROD

Fero-Grad-500 drug interactions

There are 114 drug interactions with Fero-Grad-500 (ascorbic acid/ferrous sulfate).

Fero-Grad-500 alcohol/food interactions

There are 2 alcohol/food interactions with Fero-Grad-500 (ascorbic acid/ferrous sulfate).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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