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Fero-Grad-500 (ascorbic acid / ferrous sulfate) and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Fero-Grad-500 (ascorbic acid / ferrous sulfate) which include:


ferrous sulfate food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Concomitant use of some oral medications may reduce the bioavailability of orally administered iron, and vice versa.

Food taken in conjunction with oral iron supplements may reduce the bioavailability of the iron. However, in many patients intolerable gastrointestinal side effects occur necessitating administration with food.

MANAGEMENT: Ideally, iron products should be taken on an empty stomach (i.e., at least 1 hour before or 2 hours after meals), but if this is not possible, administer with meals and monitor the patient more closely for a subtherapeutic effect. Some studies suggest administration of iron with ascorbic acid may enhance bioavailability. In addition, administration of oral iron products and some oral medications should be separated whenever the bioavailability of either agent may be decreased. Consult the product labeling for specific separation times and monitor clinical responses as appropriate.


  1. "Product Information. Accrufer (ferric maltol)." Shield Therapeutics, Wilmington, DE.
  2. "Product Information. Feosol Tablets (ferrous sulfate)." SmithKline Beecham, Philadelphia, PA.

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

ascorbic acid (vitamin C) - sodium

Ascorbic acid preparations contain sodium. The sodium content should be considered when used in patients with sodium restricted diets and conditions require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.


  1. "Product Information. Cemill (ascorbic acid)." Abbott Pharmaceutical, Abbott Park, IL.

Fero-Grad-500 (ascorbic acid / ferrous sulfate) drug interactions

There are 108 drug interactions with Fero-Grad-500 (ascorbic acid / ferrous sulfate)

Fero-Grad-500 (ascorbic acid / ferrous sulfate) disease interactions

There are 7 disease interactions with Fero-Grad-500 (ascorbic acid / ferrous sulfate) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.