Arbutamine Disease Interactions

Dobutamine and arbutamine produce stimulation of the beta receptors of the heart. The use of these agents has been associated with an increase in heart rate, ventricular ectopy, atrial fibrillation, hypertension, enhanced A-V conduction, and arrhythmias. Therapy with dobutamine or arbutamine should be administered cautiously in patients with cardiac conduction disorders.

The use of dobutamine and arbutamine has been infrequently associated with significant hypotension especially in dehydrated patients secondary to beta-2 mediated vasodilation. Hypovolemia should be corrected before administering dobutamine or arbutamine. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.

The use of dobutamine or arbutamine is contraindicated in patients with idiopathic hypertrophic subaortic stenosis (IHSS). Dobutamine or arbutamine may increase the pressure gradient within the left ventricle and thereby worsen cardiac output in patients with IHSS.