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Trasylol (aprotinin) Disease Interactions

There are 2 disease interactions with Trasylol (aprotinin):

Moderate

Aprotinin (applies to Trasylol) hypersensitivity reaction

Moderate Potential Hazard, High plausibility. Applicable conditions: Allergies

Administration of aprotinin (following an initial test dose) can result in anaphylaxis. The risk of anaphylaxis is increased when re-exposure occurs within six months of initial aprotinin therapy. Therapy with aprotinin should be administered cautiously in patients with significant allergies to other drugs or substances, since they may be at increased risk of developing an allergic reaction to aprotinin.

References

  1. "Product Information. Trasylol (aprotinin)." Bayer, West Haven, CT.
Moderate

Aprotinin (applies to Trasylol) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

The effect of renal impairment on the pharmacokinetic disposition of aprotinin has not been fully determined. During clinical trials, mild renal impairment did not substantially alter the elimination of aprotinin. However, aprotinin is primarily eliminated by the kidney and dosage reductions in patients with severe renal dysfunction may be necessary .

References

  1. "Product Information. Trasylol (aprotinin)." Bayer, West Haven, CT.

Trasylol (aprotinin) drug interactions

There are 10 drug interactions with Trasylol (aprotinin)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.