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Alvimopan Disease Interactions

There is 1 disease interaction with alvimopan:

Major

Peripheral Opioid Receptor Antagonists (Includes Alvimopan) ↔ Intestinal Obstruction

Severe Potential Hazard, Moderate plausibility

Applies to: Gastrointestinal Obstruction, Diverticulitis, Peptic Ulcer, Inflammatory Bowel Disease

Peripheral opioid receptor antagonists such as methylnaltrexone and naloxegol are contraindicated in patients with known or suspected gastrointestinal obstruction, and in patients at increased risk of recurrent obstruction, due to the potential for GI perforation. Cases of GI perforation have been reported in patients with opioid-induced constipation and advanced illness with conditions that may be associated with localized or diffuse reduction of structure integrity in the wall of the GI tract such as peptic ulcer, diverticular disease, Crohn's disease, infiltrative GI tract malignancies or peritoneal metastases. The overall risk- benefit profile should be carefully evaluated before using these agents in patients with these conditions.

alvimopan drug Interactions

There are 124 drug interactions with alvimopan

alvimopan alcohol/food Interactions

There is 1 alcohol/food interaction with alvimopan

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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