Alvimopan Disease Interactions
There is 1 disease interaction with alvimopan:
Peripheral Opioid Receptor Antagonists (Includes Alvimopan) ↔ Intestinal Obstruction
Severe Potential Hazard, Moderate plausibility
Applies to: Gastrointestinal Obstruction, Diverticulitis, Peptic Ulcer, Inflammatory Bowel Disease
Peripheral opioid receptor antagonists such as methylnaltrexone and naloxegol are contraindicated in patients with known or suspected gastrointestinal obstruction, and in patients at increased risk of recurrent obstruction, due to the potential for GI perforation. Cases of GI perforation have been reported in patients with opioid-induced constipation and advanced illness with conditions that may be associated with localized or diffuse reduction of structure integrity in the wall of the GI tract such as peptic ulcer, diverticular disease, Crohn's disease, infiltrative GI tract malignancies or peritoneal metastases. The overall risk- benefit profile should be carefully evaluated before using these agents in patients with these conditions.
alvimopan drug Interactions
There are 128 drug interactions with alvimopan
alvimopan alcohol/food Interactions
There is 1 alcohol/food interaction with alvimopan
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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