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Alprostadil Disease Interactions

There are 3 disease interactions with alprostadil:

Major

Alprostadil (applies to alprostadil) respiratory function

Major Potential Hazard, Moderate plausibility. Applicable conditions: Sepsis, Pulmonary Impairment

Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.

Moderate

Alprostadil (applies to alprostadil) bleeding

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect

Alprostadil inhibits platelet aggregation. Caution is recommended when using alprostadil injection in neonates with bleeding tendencies.

Moderate

Alprostadil (applies to alprostadil) hypotension

Moderate Potential Hazard, Moderate plausibility.

Increased peripheral blood levels of prostaglandin E1 (PGE1) and its metabolites can lead to hypotension and/or dizziness. Intracavernous injections of alprostadil can lead to increased blood levels of PGE1. Therapy with alprostadil should be administered cautiously in patients with hypotension.

References

  1. Linet OI, Ogrinc FG "Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction." N Engl J Med 334 (1996): 873-7
  2. "Intracavernous injection of alprostadil for erectile dysfunction." Med Lett Drugs Ther 37 (1995): 83-4

Alprostadil drug interactions

There are 30 drug interactions with alprostadil

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.