Edex Refill Disease Interactions
There are 3 disease interactions with Edex Refill (alprostadil).
Alprostadil (applies to Edex Refill) respiratory function
Major Potential Hazard, Moderate plausibility. Applicable conditions: Sepsis, Pulmonary Impairment
Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.
Alprostadil (applies to Edex Refill) bleeding
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect
Alprostadil inhibits platelet aggregation. Caution is recommended when using alprostadil injection in neonates with bleeding tendencies.
Alprostadil (applies to Edex Refill) hypotension
Moderate Potential Hazard, Moderate plausibility.
Increased peripheral blood levels of prostaglandin E1 (PGE1) and its metabolites can lead to hypotension and/or dizziness. Intracavernous injections of alprostadil can lead to increased blood levels of PGE1. Therapy with alprostadil should be administered cautiously in patients with hypotension.
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Edex Refill drug interactions
There are 44 drug interactions with Edex Refill (alprostadil).
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- During pregnancy
- Drug class: impotence agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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