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Edex Refill (alprostadil) Disease Interactions

There are 2 disease interactions with Edex Refill (alprostadil):

Major

Alprostadil (Includes Edex Refill) ↔ respiratory function

Severe Potential Hazard, Moderate plausibility. Applies to: Sepsis, Pulmonary Impairment

Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.

Moderate

Alprostadil (Includes Edex Refill) ↔ bleeding

Moderate Potential Hazard, Moderate plausibility. Applies to: Bleeding Associated with Coagulation Defect

Alprostadil inhibits platelet aggregation. Caution is recommended when using alprostadil injection in neonates with bleeding tendencies.

Edex Refill (alprostadil) drug interactions

There are 39 drug interactions with Edex Refill (alprostadil)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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