voriconazole (Intravenous route)Pronunciation
Commonly used brand name(s)
In the U.S.
- Vfend I.V.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antifungal
Chemical Class: Triazole
Uses For voriconazole
Voriconazole injection is used to treat certain serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (including infections in the skin, stomach, kidney, bladder, and wounds). It may also be used to treat patients with serious fungal or yeast infections who cannot tolerate other types of medicine or who do not respond to other types of medicine.
voriconazole is to be given only by or under the direct supervision of your doctor.
Before Using voriconazole
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For voriconazole, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to voriconazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of voriconazole injection in children younger than 12 years of age. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of voriconazole injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving voriconazole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using voriconazole with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Ergoloid Mesylates
- Isavuconazonium Sulfate
- St John's Wort
Using voriconazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Ado-Trastuzumab Emtansine
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Brentuximab Vedotin
- Doxorubicin Hydrochloride Liposome
- Eslicarbazepine Acetate
- Irinotecan Liposome
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Vincristine Sulfate Liposome
Using voriconazole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Estradiol Cypionate
- Estradiol Valerate
- Ethinyl Estradiol
- Ethynodiol Diacetate
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of voriconazole. Make sure you tell your doctor if you have any other medical problems, especially:
- Cancer treatment (eg, chemotherapy), recent or history of or
- Electrolyte imbalance (eg, low potassium, magnesium, calcium) or
- Heart disease, history of or
- Stem cell transplant—Use with caution. These conditions may increase your risk of having serious side effects.
- Heart rhythm problems (eg, arrhythmia, QT prolongation) or
- Liver disease (including cirrhosis) or
- Kidney disease or
- Pancreas problems—Use with caution. May make these conditions worse.
- Hypocalcemia (low calcium in the blood), uncorrected or
- Hypokalemia (low potassium in the blood), uncorrected or
- Hypomagnesemia (low magnesium in the blood)—Use with caution. These should be corrected first before starting treatment and during treatment with voriconazole.
Proper Use of voriconazole
A nurse or other trained health professional will give you or your child voriconazole. It is given through a needle placed into one of your veins. It will be given slowly, so your IV tube should stay in place for up to 2 hours.
Your doctor will give you or your child a few doses of voriconazole until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
voriconazole comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
Precautions While Using voriconazole
It is very important that your doctor check you or your child closely while you are receiving voriconazole. This is to make sure that voriconazole is working properly. Blood and urine tests will be needed to check for unwanted effects.
If your or your child's symptoms do not improve within a few days or if they become worse, check with your doctor.
Using voriconazole while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
You or your child should not use astemizole (Hismanal®), barbiturates (eg, phenobarbital, Luminal®), carbamazepine (Tegretol®), cisapride (Propulsid®), efavirenz (Sustiva®), ergot medicines (eg, dihydroergotamine, ergotamine, Cafergot®, Ergomar®, Wigraine®), pimozide (Orap®), quinidine (Quinaglute®), rifabutin (Mycobutin®), rifampin (Rifadin®, Rimactane®), ritonavir (Norvir®), sirolimus (Rapamune®), St. John's wort, or terfenadine (Seldane®).Using any of them together with voriconazole may increase the chance of unwanted effects.
voriconazole may cause some people to have changes in vision, such as blurred vision and seeing bright spots or wavy lines. Make sure you know how you react to voriconazole before you drive (especially at night), use machines, or do anything else that could be dangerous if you cannot see well.
Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Contact your doctor right away if you or your child have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem, such as QT prolongation.
voriconazole may cause a serious type of allergic reaction, called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you or your child have a fever, chills, flushing, itching or skin rash, shortness of breath, sweating, trouble breathing, lightheadedness, fainting, or chest tightness within a few hours after you receive it.
Voriconazole may increase your or your child's risk of having kidney problems, including acute kidney failure. Check with your doctor right away if you have blood in the urine, decreased urine output, muscle twitching, nausea, rapid weight gain, seizures, decreased awareness or responsiveness, severe sleepiness, swelling of the face, ankles, or hands, or unusual tiredness or weakness.
Pancreatitis may occur while you or your child are receiving voriconazole. Check with your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
voriconazole may make your skin more sensitive to sunlight. Use sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
Serious skin reactions can occur during treatment with voriconazole. Check with your doctor right away if you or your child have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using voriconazole.
voriconazole may cause bone pain when used for a long period of time. Check with your doctor right away if you or your child have bone pain while using voriconazole.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
voriconazole Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- Difficulty seeing at night
- increased sensitivity of the eyes to sunlight
- vision changes
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- clay-colored stools
- dark urine
- decreased urine
- dry mouth
- faintness or lightheadedness when getting up suddenly from a lying or sitting position
- feeling of warmth
- increased thirst
- irregular or pounding heartbeat
- loss of appetite
- muscle pain or cramps
- muscle spasms or twitching
- numbness or tingling in the hands, feet, or lips
- pounding in the ears
- rapid weight gain
- rash with flat lesions or small raised lesions on the skin
- redness of the face, neck, arms, and occasionally, the upper chest
- slow or fast heartbeat
- stomach pain
- unpleasant breath odor
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
- Black, bloody, or tarry stools
- bleeding gums
- blood in the eye
- blood in the urine or stools
- chest pain
- eye pain
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- redness in the white part of the eyes
- seeing things that are not there
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- trouble breathing with activity
- unusual bleeding or bruising
- Bone pain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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- Drug class: azole antifungals
- Voriconazole Injection
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- Voriconazole Tablets
- Voriconazole (Advanced Reading)
Other brands: Vfend