Mitomycin (Topical application)
Generic Name: mitomycin (mye-toe-MYE-sin, eye-soe-PROE-pil AL-ka-hol)
Medically reviewed by Drugs.com. Last updated on Nov 5, 2020.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Uses for mitomycin
Mitomycin topical eye solution is used to help in glaucoma surgery. Mitomycin belongs to the group of medicines called antimetabolites.
Mitomycin is to be applied only by or under the immediate supervision of your doctor.
Before using mitomycin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mitomycin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to mitomycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of mitomycin topical eye solution in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mitomycin topical eye solution in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving mitomycin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using mitomycin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Varicella Virus Vaccine, Live
- Zoster Vaccine, Live
Using mitomycin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine
- Bacillus of Calmette and Guerin Vaccine, Live
- Cholera Vaccine, Live
- Dengue Tetravalent Vaccine, Live
- Influenza Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Yellow Fever Vaccine
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of mitomycin. Make sure you tell your doctor if you have any other medical problems, especially:
- Cataracts or
- Hypotonia (decreased tension or pressure in the eye) or
- Lens implant—Use with caution. May increase the likelihood of side effects.
Proper use of mitomycin
A doctor or other trained health professional will apply mitomycin to your eyes using sponges during glaucoma filtration surgery.
Precautions while using mitomycin
Your doctor will check you closely while you are using mitomycin. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.
Using mitomycin while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using mitomycin, tell your doctor right away.
If itching, redness, swelling, or other signs of eye or eyelid irritation occur, check with your doctor. These signs may mean that you are allergic to mitomycin.
Mitomycin side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- blurred vision or other change in vision
- decreased vision
- dislocated eye implants
- eye pain
- eye redness
- flashes of light or floaters in vision
- irritation or inflammation of the eye
- seeing flashes or sparks of light
- seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
- tearing of the eyes
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Opening of the surgical wound
- raising of the upper eyelid
- sensitivity of the eyes to light
- throbbing pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about mitomycin ophthalmic
- Side Effects
- During Pregnancy
- Dosage Information
- En Español
- Drug class: miscellaneous ophthalmic agents
- FDA Alerts (1)
- Other brands
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.