Generic Name: regadenoson (Intravenous route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Diagnostic Agent, Cardiac Function
Pharmacologic Class: Adenosine A2a Receptor Agonist
Uses For Lexiscan
Regadenoson injection is used as a pharmacologic stress agent for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress. This medicine works by dilating the arteries of the heart and increase blood flow to help identify coronary artery disease.
This medicine is to be given only by or under the direct supervision of a doctor.
Before Using Lexiscan
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of regadenoson injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of regadenoson injection in the elderly. However, elderly patients are more likely to have low blood pressure, which may require caution in patients receiving regadenoson injection.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Angina, unstable or
- Unstable heart or blood vessel problem (eg, cardiovascular instability)—Avoid use, as this drug may increase the risk for heart attack.
- Breathing problems or lung disease (eg, asthma, bronchoconstriction, COPD) or
- Heart rhythm problems (eg, atrial fibrillation, atrial flutter) or
- Hypertension (high blood pressure) or
- Hypotension (low blood pressure) or
- Seizures or
- Stroke, history of—Use with caution. May make these conditions worse.
- Heart block, second or third degree (type of abnormal heart rhythm), without a pacemaker or
- Sinus node dysfunction (type of abnormal heart rhythm), without a pacemaker—Should not be used in patients with these conditions, unless patients have a pacemaker that works.
- Heart or blood vessel disease (eg, coronary artery stenosis, ischemia, pericarditis) or
- Heart valve disease or
- Hypovolemia (low blood volume)—May increase risk for more serious side effects.
Proper Use of Lexiscan
A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins.
Precautions While Using Lexiscan
It is very important that your doctor check your progress very closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.
This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you start having a rash, itching, increased heart rate, lightheadedness or fainting, trouble breathing, trouble swallowing, swelling of your hands, face, mouth, or throat, or chest pain after you receive the medicine.
Heart attack, stroke, and death may occur after receiving this medicine. Make sure your doctor knows if you have any heart problems (eg, unstable angina or cardiovascular instability) before you have a heart stress test. Check with your doctor right away if you have chest pain or discomfort, nausea, pain or discomfort in arms, jaw, back or neck, sweating, or vomiting.
Make sure your doctor knows if you are using dipyridamole (Persantine®) before you receive this medicine. You may need to stop using dipyridamole for at least 2 days before the test, if possible.
Make sure your doctor knows if you are using aminophylline or theophylline (Theo-24®, Uniphyl®) before you receive this medicine. You may need to stop using aminophylline or theophylline for at least 12 hours before the test.
Do not take anything that contains caffeine for at least 12 hours before you receive this medicine. This includes medicines, foods, and beverages with caffeine, such as coffee, tea, and cola drinks.
Lexiscan Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- Arm, back, or jaw pain
- chest pain or discomfort
- difficult or labored breathing
- fast or irregular heartbeat
- tightness in the chest
- difficulty swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- irregular heartbeat recurrent
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rash, hives, or itching skin
- trembling or shaking of the hands or feet
- unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdose
- feeling of warmth
- increased heart rate
- redness of the face, neck, arms, and occasionally, upper chest
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Change in taste
- loss of taste
- stomach soreness or discomfort
- difficulty with moving
- joint pain
- muscle aching or cramping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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More about Lexiscan (regadenoson)
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- Drug class: cardiac stressing agents