Immune globulin-slra (Intravenous)
Generic Name: immune globulin intravenous (i-MUNE GLOB-ue-lin - slra)
Medically reviewed by Drugs.com. Last updated on Jan 9, 2020.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Immune Serum
Uses for immune globulin-slra
Immune globulin-slra injection contains antibodies that make your immune system stronger. It is used for patients who have primary humoral immunodeficiency (PI), including congenital agammaglobulinemia, common variable immunodeficiency, X-linked agammaglobulinemia, Wiskott-Aldrich syndrome, and other severe combined immune system problems.
Immune globulin-slra is to be given only by or under the supervision of your doctor.
Before using immune globulin-slra
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For immune globulin-slra, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to immune globulin-slra or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of immune globulin-slra injection in children younger than 3 years of age. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of immune globulin-slra injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving immune globulin-slra.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of immune globulin-slra. Make sure you tell your doctor if you have any other medical problems, especially:
- Blood clotting problems or
- Diabetes or
- Heart or blood vessel disease or
- Hyperproteinemia (high protein in the blood) or
- Hyperviscosity (thick blood) or
- Hypovolemia (low blood volume or major loss of body fluids) or
- Paraproteinemia (paraproteins in the blood) or
- Sepsis (serious infection in the body)—Use with caution. May cause side effects to become worse.
- Bleeding problems, history of or
- Hyponatremia (low sodium in the blood) or
- Kidney problems—Use with caution. May make these conditions worse.
- IgA (immunoglobulin A) deficiency with antibodies against IgA—Should not be used in patients with this condition.
Proper use of immune globulin-slra
A doctor or other trained health professional will give you immune globulin-slra in a medical facility. It is given through a needle placed into one of your veins.
Precautions while using immune globulin-slra
It is very important that your doctor check your or your child's progress closely for any problems that may be caused by immune globulin-slra. Blood and urine tests may be needed to check for unwanted effects.
Immune globulin-slra may cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hives, chest pain, dizziness or lightheadedness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after using immune globulin-slra. Certain people, including those with IgA (an immunoglobulin) deficiency and antibodies against IgA and a history of hypersensitivity to human immunoglobulin products should not use immune globulin-slra.
Immune globulin-slra may increase your risk of developing blood clots. Check with your doctor right away if you or your child have swelling and pain in your arms, legs, or stomach, chest pain, shortness of breath, loss of sensation, confusion, or problems with muscle control or speech.
Check with your doctor right away if you start to have a stiff neck, drowsiness, fever, severe headache, nausea, vomiting, painful eye movements, or eye sensitivity to light. These could be symptoms of a serious condition called aseptic meningitis syndrome (AMS).
Check with your doctor right away if you start having red or dark brown urine, lower back or side pain, sudden weight gain, swollen face, arms, or legs, decreased urine output, or any problems with urination after you receive immune globulin-slra. These may be symptoms of a serious kidney problem.
Immune globulin-slra may cause bleeding (hemolysis) or hemolytic anemia. Tell your doctor right away if you have stomach or back pain, dark urine, decreased urination, difficulty with breathing, an increased heart rate, tiredness, or yellow eyes or skin after you receive the medicine.
Check with your doctor right away if you start having chest pain, difficult, fast, or noisy breathing, blue lips and fingernails, fever, pale skin, increased sweating, coughing that sometimes produces a pink frothy sputum, or swelling of the legs and ankles after receiving immune globulin-slra. These may be symptoms of a serious lung problem.
Immune globulin-slra is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor if you have concerns about this risk.
Make sure any doctor or dentist who treats you knows that you are using immune globulin-slra. Immune globulin-slra may affect the results of certain medical tests. Make sure any doctor or dentist who treats you knows that you are using immune globulin-slra. Immune globulin-slra may affect the results of certain medical tests.
While you are being treated with immune globulin injection, do not have any immunizations (vaccines) without your doctor's approval.
Immune globulin-slra side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Body aches or pain
- cough producing mucus
- ear congestion
- loss of appetite
- loss of voice
- muscle aches
- pain or tenderness around the eyes and cheekbones
- sore throat
- stomach pain
- stuffy or runny nose
- tightness of the chest
- troubled breathing
- unusual tiredness or weakness
Incidence not known
- Blistering, peeling, or loosening of the skin
- bloody, black, or tarry stools
- bluish color of the fingernails, lips, skin, palms, or nail beds
- chest pain
- dark urine
- feeling unusually cold
- high fever
- itching skin
- joint or muscle pain
- light-colored stools
- loss of consciousness
- painful or difficult urination
- pale skin
- red skin lesions, often with a purple center
- red, irritated eyes
- sores, ulcers, or white spots in the mouth or on the lips
- swollen glands
- unexplained bleeding or bruising
- unusual bleeding or bruising
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Muscle spasms
- Arm or leg pain
- mouth or throat pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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