Avacincaptad pegol (Intraocular)

Generic name: avacincaptad pegol [ a-va-sin-KAP-tad-PEG-ol ]
Brand name: Izervay
Drug class: Anti-angiogenic ophthalmic agents

Medically reviewed by Drugs.com. Last updated on Jan 1, 2024.

Uses for avacincaptad pegol

Avacincaptad pegol injection is used to treat geographic atrophy (GA) secondary to age-related macular degeneration (AMD). AMD is a disorder of the retina in the eye that causes blurred vision or blindness.

This medicine is to be given only by your doctor.

Before using avacincaptad pegol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of avacincaptad pegol injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of avacincaptad pegol injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Detached retina (eye disorder) or
• Endophthalmitis (inflammation of the eye) or
• Increased pressure in the eye or
• Neovascular (wet) age-related macular degeneration (AMD)—Use with caution. May make these conditions worse.

• Eye infection or
• Eye swelling, active—Should not be used in patients with these conditions.

Related/similar drugs

Vabysmo, Eylea, Syfovre, Izervay, ranibizumab ophthalmic, Lucentis, aflibercept ophthalmic

Proper use of avacincaptad pegol

An ophthalmologist (eye doctor) will give you this medicine as a shot into the eye. This medicine is usually given once a month for up to 12 months.

Precautions while using avacincaptad pegol

Your eye doctor will want to check your progress closely and at regular visits, especially during the first few days after you receive this medicine, to make sure this medicine is working properly and to check for unwanted effects.

Serious eye or vision problems (eg, retinal detachment, endophthalmitis, eye infection, increased pressure inside the eye, or neovascular AMD) may occur with this medicine. Check with your eye doctor right away if your have blurred or other change in vision, eye pain, eye redness, headache, seeing flashes or sparks of light, seeing floating spots before the eyes, or a veil or curtain appearing across part of vision, tearing of the eyes several days after you receive this medicine.

This medicine may cause temporary blurred vision. Do not drive or do anything else that could be dangerous until you can see clearly.

Side Effects of avacincaptad pegol

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Bloody eye
• blurred vision
• change in vision
• loss of vision
• redness of the eye

Less common

• Decrease in vision
• eye pain
• redness, swelling, or itching of the eyelid
• seeing floating dark spots or material before the eyes

Incidence not known

• Seeing flashes or sparks of light
• seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
• tearing of the eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Commonly used brand name(s)

In the U.S.

• Izervay

Available Dosage Forms:

• Solution

Therapeutic Class: Ophthalmologic Agent

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer