aminophylline (Oral route)Pronunciation
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Tablet, Extended Release
Therapeutic Class: Bronchodilator
Chemical Class: Theophylline
Uses For aminophylline
Aminophylline is used together with other medicine to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases.
Aminophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.
aminophylline is available only with your doctor's prescription.
Before Using aminophylline
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aminophylline, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to aminophylline or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of aminophylline in children. However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving aminophylline.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aminophylline in the elderly. However, elderly patients may be more sensitive to the effects of aminophylline than younger adults, which may require caution and an adjustment in the dose for patients receiving aminophylline.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aminophylline, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using aminophylline with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using aminophylline with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Estradiol Cypionate
- Estradiol Valerate
- Ethinyl Estradiol
- Ethynodiol Diacetate
- Medroxyprogesterone Acetate
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
Using aminophylline with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Interferon Alfa-2a
- St John's Wort
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using aminophylline with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aminophylline, or give you special instructions about the use of food, alcohol, or tobacco.
Using aminophylline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aminophylline, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of aminophylline. Make sure you tell your doctor if you have any other medical problems, especially:
- Congestive heart failure or
- Cor pulmonale (heart condition) or
- Fever of 102 degrees F or higher for 24 hours or more or
- Hypothyroidism (underactive thyroid) or
- Infection, severe (e.g., sepsis) or
- Kidney disease in infants younger than 3 months of age or
- Liver disease (e.g., cirrhosis, hepatitis) or
- Pulmonary edema (lung condition) or
- Shock (serious condition with very little blood flow in the body)—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Heart rhythm problems (e.g., arrhythmia) or
- Seizures, or history of or
- Stomach ulcer—Use with caution. May make these conditions worse.
Proper Use of aminophylline
Take aminophylline exactly as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. aminophylline works best if there is a constant amount in the blood. To keep the blood level constant, take aminophylline at the same time each day and do not miss any doses.
After you or your child begin taking aminophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. Keep all appointments for testing the blood level.
The dose of aminophylline will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of aminophylline. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- To treat symptoms of asthma, bronchitis, and emphysema:
- Adults, teenagers, and children above 1 year of age weighing more than 45 kilograms (kg)—At first, 380 milligrams (mg) per day, divided and given every 6 to 8 hours. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 760 mg per day.
- Older adults—The dose must be determined by your doctor. However, the total dose is usually not more than 507 milligrams per day, divided and given every 6 to 8 hours.
- Children and teenagers 1 to 15 years of age weighing less than 45 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. At first, the dose is 15.2 to 17.7 milligrams (mg) per kg of body weight per day, divided and given every 4 to 6 hours. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 25.3 mg per kg of body weight per day or 760 mg per day.
- Infants younger than 1 year of age—Use and dose must be determined by your doctor.
- To treat symptoms of asthma, bronchitis, and emphysema:
If you miss a dose of aminophylline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using aminophylline
It is very important that your doctor check the progress of you or your child at regular visits, especially for the first few weeks after you begin using aminophylline. Blood tests may be needed to check for unwanted effects.
A change in your usual behavior or physical well-being may affect the way aminophylline works in your body. Tell your doctor if you or your child:
- Have had a fever of 102 degrees F or higher for at least 24 hours or more.
- Have started or stopped smoking tobacco or marijuana in the last few weeks.
- Have started or stopped taking another medicine in the last few weeks.
- Have changed your diet in the last few weeks.
Stop using aminophylline and check with your doctor right away if you or your child have the following symptoms while using aminophylline: nausea or vomiting that continues, headaches, trouble with sleeping, seizures, or irregular heartbeats.
Do not stop or change the dose of aminophylline without checking first with your doctor.
Before you have any medical tests, tell the medical doctor in charge that you or your child are using aminophylline. The results of some tests may be affected by aminophylline.
aminophylline may add to the central nervous system (CNS) stimulant effects of caffeine-containing foods or beverages such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while using aminophylline. If you have questions about this, check with your doctor.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.
aminophylline Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:Rare
- Cracks in the skin
- loss of heat from the body
- red, swollen skin
- scaly skin
- skin rash
- Chest pain or discomfort
- fast, slow, or irregular heartbeat
- increase in urine volume
- persistent vomiting
- pounding or rapid pulse
Get emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdose
- Abdominal or stomach pain
- blurred vision
- confusion about identity, place, and time
- dark-colored urine
- decrease in frequency of urination
- decreased urine
- difficulty in passing urine (dribbling)
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast, pounding, or irregular heartbeat or pulse
- increased thirst
- irregular heartbeat
- loss of appetite
- mood changes
- muscle cramps or spasms
- muscle pain or stiffness
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- pain or discomfort in the arms, jaw, back, or neck
- painful urination
- shakiness in the legs, arms, hands, or feet
- shortness of breath
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- trouble sleeping
- unable to sleep
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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