Comparing Penicillamine vs Syprine

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Penicillamine

Syprine trientine

Prescribed for Wilson's Disease, Cystinuria, Rheumatoid Arthritis. penicillamine may also be used for purposes not listed in this medication guide.

Prescribed for Wilson's Disease. Syprine may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

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Drug Class

Antirheumatics

Chelating agents

Side Effects

Commonly reported side effects include: cheilosis, epigastric pain, glossitis, oral mucosa ulcer, ageusia, and dysgeusia.

See the full penicillamine side effects document.

See the full Syprine side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	100 capsule
Dosage	250 mg
Per Unit^*	$95.51 - $253.86
Cost^*	$9,551.08 - $25,386.29

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Quantity	100 capsule
Dosage	250 mg
Per Unit^*	$222.12
Cost^*	$22,212.04

View all Syprine prices and generic prices

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Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available

Oral capsule
Oral tablet

Oral capsule

Brand Names

Cuprimine, D-Penamine, Depen, Depen Titratabs Other trientine brands include: Clovique

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

3.2 hours

N/A

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 91 drugs are known to interact with penicillamine:

21 major drug interactions (106 brand and generic names)
70 moderate drug interactions (1484 brand and generic names)

A total of 40 drugs are known to interact with Syprine:

36 moderate drug interactions (1372 brand and generic names)
4 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

You may experience reduced absorption of penicillAMINE in the presence of food. The effectiveness... View more

Take trientine on an empty stomach 1 hour before or 2 hours after a meal and at least one hour... View more

Disease Interactions

Iron-deficiency anemia

First Approval Date

December 04, 1970

November 08, 1985

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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