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Comparing Penicillamine vs Syprine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Penicillamine Syprine
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Penicillamine Syprine (trientine)
Prescription only

Prescribed for Cystinuria, Wilson's Disease, Rheumatoid Arthritis. penicillamine may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Wilson's Disease. Syprine may also be used for purposes not listed in this medication guide.

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More about Penicillamine More about Syprine (trientine)
Generic Status

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

Penicillamine has an average rating of 9.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.

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Drug Class
Side Effects

Commonly reported side effects include:

  • cheilosis
  • epigastric pain
  • glossitis
  • oral mucosa ulcer
  • ageusia
  • dysgeusia

See also: penicillamine side effects in more detail.

See also: Syprine side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 100 capsule
Dosage 250 mg
Per Unit* $95.51 - $253.86
Cost* $9,551.08 - $25,386.29

View all penicillamine prices

Quantity 100 capsule
Dosage 250 mg
Per Unit* $224.03
Cost* $22,403.44

View all Syprine prices and generic prices

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Dosage Form(s) Available
  • Oral capsule
  • Oral tablet
  • Oral capsule
Brand Names
Cuprimine, D-Penamine, Depen, Depen Titratabs Other trientine brands include: Clovique, Cuvrior
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

3.2 hours

N/A
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 92 drugs are known to interact with penicillamine:

  • 21 major drug interactions (106 brand and generic names)
  • 71 moderate drug interactions (1554 brand and generic names)

A total of 40 drugs are known to interact with Syprine:

  • 36 moderate drug interactions (1440 brand and generic names)
  • 4 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • You may experience reduced absorption of penicillAMINE in the presence of food. The effectiveness... View more
  • Take trientine on an empty stomach 1 hour before or 2 hours after a meal and at least one hour... View more
Disease Interactions
First Approval Date

December 04, 1970

November 08, 1985
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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