Comparing Kuvan vs Palynziq

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Kuvan Remove Kuvan from your drug comparison	Palynziq Remove Palynziq from your drug comparison	Add another drug to compare

Kuvan sapropterin

Palynziq pegvaliase

Prescribed for Phenylketonuria. Kuvan may also be used for purposes not listed in this medication guide.

Prescribed for Phenylketonuria. Palynziq may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

Review this drug

Drug Class

Miscellaneous metabolic agents

Miscellaneous metabolic agents

Side Effects

Common side effects include: headache, and rhinorrhea.

See the full Kuvan side effects document.

See the full Palynziq side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 powder for reconstitution
Dosage	100 mg
Per Unit^*	$44.16
Cost^*	$1,324.94

View all Kuvan prices and generic prices

Quantity	1 mL
Dosage	20 mg/mL
Per Unit^*	$595.18
Cost^*	$595.18

View all Palynziq prices

Get free Discount Card

Generic Availability

Yes

Dosage Form(s) Available

Oral powder for reconstitution
Oral tablet, soluble

Subcutaneous solution

Brand Names

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

17 hours

60 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Summary unavailable.

See the full Pregnancy Warnings document.

Drug Interactions

A total of 20 drugs are known to interact with Kuvan:

20 moderate drug interactions (100 brand and generic names)

A total of 17 drugs are known to interact with Palynziq:

17 moderate drug interactions (89 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Food increases the absorption of sapropterin. Sapropterin should be administered with food... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

First Approval Date

December 13, 2007

N/A

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer