Kuvan Disease Interactions
There are 4 disease interactions with Kuvan (sapropterin).
Sapropterin (applies to Kuvan) gastritis
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Duodenitis/Gastritis
During clinical studies with sapropterin, gastritis was reported as a serious adverse reaction. Monitor patients for signs and symptoms of gastritis during treatment, and use with caution in patients with a history of gastritis.
Sapropterin (applies to Kuvan) liver impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Patients with liver impairment have not been evaluated in clinical trials with sapropterin. Hepatic damage has been associated in patients with impaired phenylalanine metabolism. Caution and monitoring is advised in patients with liver impairment who are receiving treatment with sapropterin.
Sapropterin (applies to Kuvan) neurological disorders
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Neurologic Disorder
A 10-year sapropterin postmarketing-marketing safety surveillance program for a non-phenylketonuria indication, showed that a few patients with underlying neurological disorders experienced seizures, exacerbation of seizures, over-stimulation, and irritability especially when coadministered with levodopa. Patients with neurological disorders, especially those receiving levodopa should be monitored for changes in neurological status during treatment with sapropterin.
Sapropterin (applies to Kuvan) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Patients with renal impairment have not been evaluated in sapropterin clinical trials. Monitor patients who have renal impairment carefully if receiving treatment with sapropterin.
Switch to professional interaction data
Kuvan drug interactions
There are 20 drug interactions with Kuvan (sapropterin).
Kuvan alcohol/food interactions
There is 1 alcohol/food interaction with Kuvan (sapropterin).
More about Kuvan (sapropterin)
- Kuvan consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Drug images
- Latest FDA alerts (1)
- Side effects
- Dosage information
- During pregnancy
- Generic availability
- FDA approval history
- Drug class: miscellaneous metabolic agents
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Aqneursa
Aqneursa information from Drugs.com, includes Aqneursa side effects, interactions and indications.
Amvuttra
Amvuttra is used to treat polyneuropathy associated with hereditary transthyretin-mediated ...
Cerdelga
Cerdelga (eliglustat) is used to treat mild to moderate Type 1 Gaucher Disease. Includes Cerdelga ...
Crysvita
Crysvita is used for familial hypophosphatemia, osteomalacia, X-Linked Hypophosphatemia
Galafold
Galafold (migalastat) is used to treat Fabry disease. Includes Galafold side effects, interactions ...
Givlaari
Givlaari injection is used for acute hepatic porphyria (AHP) to reduce the number of acute attacks ...
Iqirvo
Iqirvo (elafibranor) is used to treat primary biliary cholangitis (PBC) in combination with ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.