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Kuvan (sapropterin) Disease Interactions

There are 4 disease interactions with Kuvan (sapropterin):

Moderate

Sapropterin (applies to Kuvan) gastritis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Duodenitis/Gastritis

During clinical studies with sapropterin, gastritis was reported as a serious adverse reaction. Monitor patients for signs and symptoms of gastritis during treatment, and use with caution in patients with a history of gastritis.

Moderate

Sapropterin (applies to Kuvan) liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Patients with liver impairment have not been evaluated in clinical trials with sapropterin. Hepatic damage has been associated in patients with impaired phenylalanine metabolism. Caution and monitoring is advised in patients with liver impairment who are receiving treatment with sapropterin.

Moderate

Sapropterin (applies to Kuvan) neurological disorders

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Neurologic Disorder

A 10-year sapropterin postmarketing-marketing safety surveillance program for a non-phenylketonuria indication, showed that a few patients with underlying neurological disorders experienced seizures, exacerbation of seizures, over-stimulation, and irritability especially when coadministered with levodopa. Patients with neurological disorders, especially those receiving levodopa should be monitored for changes in neurological status during treatment with sapropterin.

Moderate

Sapropterin (applies to Kuvan) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Patients with renal impairment have not been evaluated in sapropterin clinical trials. Monitor patients who have renal impairment carefully if receiving treatment with sapropterin.

Kuvan (sapropterin) drug interactions

There are 20 drug interactions with Kuvan (sapropterin)

Kuvan (sapropterin) alcohol/food interactions

There is 1 alcohol/food interaction with Kuvan (sapropterin)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.