Icatibant Alternatives Compared
| Icatibant | Orladeyo (berotralstat) | Firazyr (icatibant) |
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| Icatibant | Orladeyo (berotralstat) | Firazyr (icatibant) |
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Prescription only
Prescribed for Hereditary Angioedema. Icatibant may also be used for purposes not listed in this medication guide. |
Prescription only
Orladeyo is an oral, once-daily medication that is taken to reduce angioedema attacks in adults and children over the age of 12 with HAE. It is the only oral preventive currently available (the... View more |
Prescription only
Firazyr is used to treat attacks of hereditary angioedema (HAE) in adults (not children) and people can be taught how to self-administer it subcutaneously at home. Injection site reactions, such as... View more |
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| More about Icatibant | More about Orladeyo (berotralstat) | More about Firazyr (icatibant) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Icatibant has an average rating of 8.4 out of 10 from a total of 10 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 20% reported a negative effect. |
Orladeyo has an average rating of 6.7 out of 10 from a total of 3 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 0% reported a negative effect. |
Firazyr has an average rating of 7.9 out of 10 from a total of 7 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
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View all Icatibant side effects |
View all Orladeyo side effects |
View all Firazyr side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Icatibant prices |
View all Orladeyo prices |
View all Firazyr prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Firazyr |
N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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1.8 hours |
152 hours |
1.8 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 11 drugs are known to interact with Icatibant:
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A total of 524 drugs are known to interact with Orladeyo:
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A total of 11 drugs are known to interact with Firazyr:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | ||||||||||||||||||||||||||
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August 25, 2011 |
December 03, 2020 |
N/A |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.