Berinert Alternatives Compared
| Berinert | Orladeyo | Firazyr |
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| Berinert (C1 esterase inhibitor (human)) | Orladeyo (berotralstat) | Firazyr (icatibant) |
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Prescription only
Berinert is used to treat hereditary angioedema (HAE) in adults and children and people can be taught how to self-administer it intravenously at home. An increase in the severity of pain associated... View more |
Prescription only
Orladeyo is an oral, once-daily medication that is taken to reduce angioedema attacks in adults and children over the age of 12 with HAE. It is the only oral preventive currently available (the... View more |
Prescription only
Firazyr is used to treat attacks of hereditary angioedema (HAE) in adults (not children) and people can be taught how to self-administer it subcutaneously at home. Injection site reactions, such as... View more |
Related suggestions Popular comparisons
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| More about Berinert (C1 esterase inhibitor (human)) | More about Orladeyo (berotralstat) | More about Firazyr (icatibant) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Berinert has an average rating of 10.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
Orladeyo has an average rating of 6.7 out of 10 from a total of 3 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 0% reported a negative effect. |
Firazyr has an average rating of 7.9 out of 10 from a total of 7 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Berinert side effects in more detail. |
See also: Orladeyo side effects in more detail. |
See also: Firazyr side effects in more detail. |
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| Generic Availability | ||||||||||||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Berinert prices |
View all Orladeyo prices |
View all Firazyr prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other C1 esterase inhibitor (human) brands include: Cinryze, Haegarda |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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152 hours |
152 hours |
1.8 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 49 drugs are known to interact with Berinert:
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A total of 452 drugs are known to interact with Orladeyo:
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A total of 11 drugs are known to interact with Firazyr:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | ||||||||||||||||||||||||||
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N/A |
December 03, 2020 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.