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Prevnar 20 and Pain: What Users Say

Pain: mentioned by 4 users (12.9%)

Based on user experiences from 31 Prevnar 20 reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

fatigue 22.6%
chills 16.1%
headaches 16.1%
pain 12.9%
swelling 12.9%
fever 9.7%
nausea 9.7%
sore arm 9.7%
tiredness 9.7%

Reviews for Prevnar 20

Commonly mentioned side effects
  • Ant...
  • December 18, 2024

For Pneumococcal Disease Prophylaxis "I am a doctor who has been practicing for close to 50 years in a very busy practice. I am surprised by the large amount of negative feedback on different vaccines. I am not discrediting those who had negative results, I feel sorry for their experiences. Putting into consideration that those who did not have a bad side effect will usually not write a review makes the percentage of side effects very high. The side effects that I usually see are one-day-only pain or fever, except for COVID vaccines, where I have seen a very large amount of serious side effects. I hope that those who experienced bad side effects recover. We also should not forget that those who receive vaccines (of any kind) have a lesser chance of contracting disease. This is why polio and smallpox have been eradicated, and other diseases such as measles, chickenpox, TB, and mumps are very rare."

8 / 10
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14 Report
  • Mar...
  • Taken for less than 1 month
  • June 9, 2023

For Pneumococcal Disease Prophylaxis "I am an active 72-year-old female. Good health. Received an injection of Prevnar 20 as a recommended preventive vaccine during a routine check-up at the doctor's office yesterday morning. By bedtime, I was experiencing some discomfort in my lower back. At 5:00 a.m., I awoke to a great deal of pain in my lower back and especially my hips, radiating to my groin and right leg. I have taken Tylenol and used Salonpas w/ Lidocaine cream, no relief from pain. No fever, just joint pain. If I had known, I would not have taken Prevnar. I had already taken Prevnar 13 in 2018. I can tolerate pain, this pain is intense. Please ask your doctor questions about side effects before you get this injection. I read the reports online AFTER I already allowed this vaccine inside my body -- did not know it was made by Pfizer, like the COVID vaccines I also took, or I would not have gotten this vaccine."

1 / 10
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24 Report
  • Anonymous
  • Taken for less than 1 month
  • August 9, 2024

For Pneumococcal Disease Prophylaxis "I was okay until day 2. But woke up with severe pain in my left hand (side of the injection site) on day three. I could not even use my left hand at all, some swelling and severe pain when moving my hand. Also, have back and hip pains. I hope it goes away soon. Tylenol and Flexeril were no help."

5 / 10
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8 Report

Frequently asked questions

  • Sin...
  • Taken for less than 1 month
  • August 8, 2025

For Pneumococcal Disease Prophylaxis "I had this vaccine in August 2025 since I am 62 and my PA recommended it. I am ex-military and have had a ton of vaccines - Yellow Fever, TDAP, Tetanus, Measles, Covid, Flu, Monkeypox, Shingles, Hepatitis, etc. By far the one with the most side effects to me is the Covid shot, and the Shingles shot 2nd - with both of them I am usually achy and fatigued and feverish and need to lay down for most of the day afterward. The Prevnar 20 shot was NOT that. A very mild and 'child's play' type of vaccine. I got it around 3 PM and honestly forgot about it completely. That night my arm was slightly sore; I iced and rubbed some Voltaren on it. Woke up the next day and felt totally fine. No issues whatsoever and on the Vaccine Schofield Hotness Scale (I made that up) this shot was a 2 out of 10. Your mileage may vary but the number of reviews by folks are suspect and whatever they are saying may not even be attributed to a vax. If you are told to get it, get it. Pneumonia kills people."

10 / 10
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0 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.