Isoniazid and Moody: What Users Say

• Anonymous
• October 25, 2011

For Tuberculosis, Latent "I'm currently on this medication plus vitamin B6 for a positive TB skin test. I've been taking it for about 4 months now. I'm scared to death. I wonder if I will be able to go through these 9 months without serious side effects like liver damage. Haven't experienced any side effects so far. I seem okay. 5 months to go. Hopefully, nothing serious happens. I'm so moody lately. My coworkers say I now have an attitude."

• Sti...
• June 24, 2010

For Tuberculosis, Prophylaxis "I'm still here, so I guess it worked - but it was a rough, horribly rough 9 months - it helped that I was already on medical leave (and that the hospital took responsibility for the exposure) - Isoniazid is literally a sort of (failed) anti-depressant that works against TB, but is also pretty harsh on the liver, so I had to take Vitamin B6 for 9 months too. I was pretty moody, crazy, aggressive - not my normal self... it was a long 9 months. I can't understate how mood-altering this medicine was - not in a good way. I was embarrassed to talk about it, which made my behavior all the more odd to my friends and co-workers, but once I explained it, I got some support - anyhow, I wish I had done that from the start. On the plus side, I'm still here!"

• nan...
• Taken for 6 months to 1 year
• October 17, 2019

For Tuberculosis, Latent "I've been taking isoniazid 300 mg with vitamin B-6 50 mg for almost 4 months now, and I have 5 more months now - it is for tuberculosis (TB). I have been depressed and moody all day until today. I keep crying and I am not feeling good at all."

• Lat...
• Taken for 1 to 6 months
• June 11, 2022

For Tuberculosis, Latent "I've been taking isoniazid for 4.5 months now, and my mood has been deteriorating slowly but surely for the last month. I have struggled with fatigue and memory loss since the beginning, and this improved a bit since then but is still hard. But mostly now, I feel incredibly low, teary, overwhelmed, and anxious all the time. I don't feel like I can keep going, but I know I have to."