Generic Name: Vemurafenib (vem ue RAF e nib)
Brand Name: Zelboraf
Medically reviewed by Drugs.com. Last updated on Mar 31, 2019.
Uses of Zelboraf:
- It is used to treat a type of skin cancer (melanoma).
- It is used to treat a type of blood cell cancer called Erdheim-Chester disease (ECD).
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Zelboraf?
- If you have an allergy to vemurafenib or any other part of Zelboraf (vemurafenib).
- If you have any of these health problems: Low calcium levels, low magnesium levels, or low potassium levels.
- If you have a long QT on ECG.
- If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you take any other drugs (prescription or OTC, natural products, vitamins). There are many drugs that interact with Zelboraf (vemurafenib), like certain drugs that are used for HIV, infections, or seizures.
- If you are breast-feeding. Do not breast-feed while you take Zelboraf (vemurafenib) and for 2 weeks after your last dose.
This is not a list of all drugs or health problems that interact with Zelboraf (vemurafenib).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zelboraf (vemurafenib) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Zelboraf?
- Tell all of your health care providers that you take Zelboraf (vemurafenib). This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may add to the chance of getting some types of cancer. Talk with the doctor.
- You will need to have a skin exam before you start Zelboraf (vemurafenib) and every 2 months while you take it. You will also need to do monthly skin checks as told by your doctor.
- You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
- Bright lights may bother you. Wear sunglasses.
- This medicine may cause a type of abnormal heartbeat (prolonged QT interval). If this happens, the chance of other unsafe and sometimes deadly abnormal heartbeats may be raised. Talk with the doctor.
- You will need an ECG before starting Zelboraf (vemurafenib) and during treatment. Talk with your doctor.
- If you have had or will be having radiation treatment, talk with your doctor. Worse side effects from radiation treatment have happened with Zelboraf (vemurafenib). Sometimes this has been deadly.
- This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking Zelboraf (vemurafenib) with your other drugs.
- A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor.
- Bending of the fingers inward has happened with Zelboraf (vemurafenib). Sometimes, this could be very bad or disabling. Call your doctor right away if this happens to you.
- If you are 65 or older, use Zelboraf (vemurafenib) with care. You could have more side effects.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking Zelboraf (vemurafenib) and for at least 2 weeks after stopping the drug.
- If you get pregnant while taking Zelboraf (vemurafenib) or within 2 weeks after your last dose, call your doctor right away.
How is this medicine (Zelboraf) best taken?
Use Zelboraf (vemurafenib) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Swallow whole. Do not chew or crush.
- Take with a full glass of water.
- If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.
- To gain the most benefit, do not miss doses.
- Keep taking Zelboraf (vemurafenib) as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If the next dose is less than 4 hours away, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Dizziness or passing out.
- A fast heartbeat.
- A heartbeat that does not feel normal.
- Swelling in the arms or legs.
- A skin lump or growth.
- Redness, irritation, pain, or thick skin on the palms of the hands or soles of the feet.
- Change in eyesight, eye pain, or very bad eye irritation.
- A burning, numbness, or tingling feeling that is not normal.
- Very bad headache.
- Have your skin checked. Tell your doctor if you have any skin changes like a new wart, skin sore or reddish bump that bleeds or does not heal, or a change in the color or size of a mole.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
What are some other side effects of Zelboraf?
- Hair loss.
- Muscle or joint pain.
- Back pain.
- Upset stomach or throwing up.
- Change in taste.
- Feeling tired or weak.
- Not hungry.
- Dry skin.
If OVERDOSE is suspected:
How do I store and/or throw out Zelboraf?
- Store in the original container at room temperature.
- Keep lid tightly closed.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Zelboraf (vemurafenib) is refilled. If you have any questions about Zelboraf (vemurafenib), please talk with the doctor, pharmacist, or other health care provider.
More about Zelboraf (vemurafenib)
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug Interactions
- Compare Alternatives
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- 4 Reviews
- Drug class: multikinase inhibitors
- FDA Approval History